The goal of this continuation project, submitted in response to PA-10-009 (Bioengineering Research Grants), is to develop new technology and to generate new knowledge that will accelerate the development of implants and surgical approaches to treat presbyopia. The project addresses two critical barriers: a) the need for instruments and techniques that measure the accommodative response and are suitable for clinical and objective evaluation of techniques to restore accommodation and b) the need to advance our understanding of the causes of presbyopia and discover the most effective strategies for restoration of accommodation. The project has three specific aims:
Aim 1 : To develop technology to simultaneously quantify the optical and mechanical in vivo accommodative response of the human eye. Optical coherence tomography systems, a dynamic aberrometer, an accommodation stimulus, and image processing software will be developed and integrated into a combined imaging and biometry system that will allow simultaneous measurement of the axial eye length, lens shape, lens internal structure, ciliary muscle geometry, and ocular refraction and aberrations in response to monocular accommodative stimuli.
Aim 2 : To characterize the age-dependence of the optical and anatomical changes in the lens and ciliary muscle with accommodation. The system developed in Aim 1 will be used to characterize the age-dependence of the accommodation-induced dynamic changes in outer and nuclear lens curvature;lens thickness and power;nuclear thickness and power;and ciliary muscle geometry. Data will be acquired on 200 human subjects from age 16 to 66. The results will be used to quantify the contribution of the lens and ciliary muscle to the loss of accommodation with age.
Aim 3 : To compare the pseudophakic accommodative response in subjects implanted with standard and accommodating intraocular lenses. The system developed in Aim 1 will be used to measure and compare the accommodation-induced changes in ciliary muscle geometry, intraocular lens position and ocular refraction in subjects implanted with standard monofocal intraocular lenses and subjects implanted with accommodating intraocular lenses. The results will be used to identify the parameters that govern near visual function in subjects with intraocular lenses. The project will have a broad impact on the field of presbyopia research. It will produce new technology to quantify the ocular accommodative response and evaluate the efficacy of procedures to restore accommodation. It will generate new knowledge on the causes of presbyopia and identify parameters that govern near-visual function in eyes with intraocular lenses. The knowledge gained will form a sound physiological basis for the development and optimization of new procedures and implants designed to restore accommodation.

Public Health Relevance

Presbyopia is the age-related gradual loss of the ability of the eye to focus on near objects. Presbyopia affects a fast-growing segment of our population, virtually everyone age 45 and above. Presbyopes are increasingly reliant on technologies for which good near-vision is important. Biomedical strategies that can restore normal near-visual function will significantly improve the quality of life for these physically- and socially- active members of our society. This project seeks to improve our understanding of the age-related changes in the eye leading to presbyopia and to test approaches to correct presbyopia.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY014225-10
Application #
8609032
Study Section
Special Emphasis Panel (NOIT)
Program Officer
Wiggs, Cheri
Project Start
2002-09-30
Project End
2017-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
10
Fiscal Year
2014
Total Cost
$367,973
Indirect Cost
$109,254
Name
University of Miami School of Medicine
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Ruggeri, Marco; de Freitas, Carolina; Williams, Siobhan et al. (2016) Quantification of the ciliary muscle and crystalline lens interaction during accommodation with synchronous OCT imaging. Biomed Opt Express 7:1351-64
Augusteyn, Robert C; Maceo Heilman, Bianca; Ho, Arthur et al. (2016) Nonhuman Primate Ocular Biometry. Invest Ophthalmol Vis Sci 57:105-14
Wu, Chen; Han, Zhaolong; Wang, Shang et al. (2015) Assessing age-related changes in the biomechanical properties of rabbit lens using a coaligned ultrasound and optical coherence elastography system. Invest Ophthalmol Vis Sci 56:1292-300
Maceo Heilman, Bianca; Manns, Fabrice; de Castro, Alberto et al. (2015) Changes in monkey crystalline lens spherical aberration during simulated accommodation in a lens stretcher. Invest Ophthalmol Vis Sci 56:1743-50
Neri, Alberto; Ruggeri, Marco; Protti, Alessandra et al. (2015) Dynamic imaging of accommodation by swept-source anterior segment optical coherence tomography. J Cataract Refract Surg 41:501-10
Hernandez, Victor M; Cabot, Florence; Ruggeri, Marco et al. (2015) Calculation of crystalline lens power using a modification of the Bennett method. Biomed Opt Express 6:4501-15
Nankivil, Derek; Maceo Heilman, Bianca; Durkee, Heather et al. (2015) The zonules selectively alter the shape of the lens during accommodation based on the location of their anchorage points. Invest Ophthalmol Vis Sci 56:1751-60
Pour, Hooman Mohammad; Kanapathipillai, Sangarapillai; Zarrabi, Khosrow et al. (2015) Stretch-dependent changes in surface profiles of the human crystalline lens during accommodation: a finite element study. Clin Exp Optom 98:126-37
Marussich, Lauren; Manns, Fabrice; Nankivil, Derek et al. (2015) Measurement of Crystalline Lens Volume During Accommodation in a Lens Stretcher. Invest Ophthalmol Vis Sci 56:4239-48
Augusteyn, Robert C (2014) Growth of the eye lens: I. Weight accumulation in multiple species. Mol Vis 20:410-26

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