Human refractive error typically diminishes over the first postnatal year, while the neural system is undergoing significant development. Progression of both processes is critically dependent on visual experience and the quality of the retinal image. Retinal image quality, however, is likely to be compromised in young infants due to accommodative immaturities. This proposal will examine the accommodative abilities of infants and qualify the real-time impact of immaturities on retinal image quality during the first postnatal year. These data will enable a refined understanding of the interdependence of accommodation, neural resolution and emmetropization in human development, as well as determine the impact of each on manifest visual function.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY014460-02
Application #
6769505
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Oberdorfer, Michael
Project Start
2003-07-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
2
Fiscal Year
2004
Total Cost
$217,109
Indirect Cost
Name
Indiana University Bloomington
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Seemiller, Eric S; Port, Nicholas L; Candy, T Rowan (2018) The gaze stability of 4- to 10-week-old human infants. J Vis 18:15
Chen, Angela M; Manh, Vivian; Candy, T Rowan (2018) Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia. Invest Ophthalmol Vis Sci 59:2187-2196
Wu, Yifei; Thibos, Larry N; Candy, T Rowan (2018) Two-dimensional simulation of eccentric photorefraction images for ametropes: factors influencing the measurement. Ophthalmic Physiol Opt 38:432-446
Seemiller, Eric S; Cumming, Bruce G; Candy, T Rowan (2018) Human infants can generate vergence responses to retinal disparity by 5 to 10 weeks of age. J Vis 18:17
Troyer, Mary E; Sreenivasan, Vidhyapriya; Peper, T J et al. (2017) The heterophoria of 3-5 year old children as a function of viewing distance and target type. Ophthalmic Physiol Opt 37:7-15
Wu, Yifei; Sreenivasan, Vidhyapriya; Babinsky, Erin E et al. (2016) Adaptation of horizontal eye alignment in the presence of prism in young children. J Vis 16:6
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2016) Vergence Adaptation to Short-Duration Stimuli in Early Childhood. Invest Ophthalmol Vis Sci 57:920-7
Sreenivasan, Vidhyapriya; Babinsky, Erin E; Wu, Yifei et al. (2016) Objective Measurement of Fusional Vergence Ranges and Heterophoria in Infants and Preschool Children. Invest Ophthalmol Vis Sci 57:2678-88
Seemiller, Eric S; Wang, Jingyun; Candy, T Rowan (2016) Sensitivity of vergence responses of 5- to 10-week-old human infants. J Vis 16:20
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2015) Near heterophoria in early childhood. Invest Ophthalmol Vis Sci 56:1406-15

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