The postnatal development of both the optical and neural visual systems is dependent on visual experience. Visual experience is defined by the information available in the retinal images in the two eyes. The goal of the proposed research is to extend our previous examination of retinal image quality in one eye during infancy to full binocular viewing conditions. We will examine human infants'visual experience in the context of image clarity and image alignment, which are primarily defined by accommodation and vergence responses and their interaction. These studies will document the emergence of the interaction between accommodation and vergence and their role in the development of refractive and accommodative strabismus. There are three specific aims: i) To understand the normal maturation of the relationship between accommodation and vergence with emmetropisation and growth of the distance between the eyes. ii) To determine the relative bias towards accommodation or vergence accuracy during the critical period of human development. iii) To understand the effects of accommodation and vergence behavior on visual experience of infants and children with high hyperopia or strabismus.

Public Health Relevance

This project will determine how young infants and children manage apparently conflicting focusing and eye alignment demands during typical development. It will also investigate why some children develop refractive or accommodative strabismus while others, with apparently matching visual systems, do not. The goal is to develop intervention strategies to prevent this strabismus and associated amblyopia.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY014460-09
Application #
8225355
Study Section
Special Emphasis Panel (ZRG1-IFCN-G (02))
Program Officer
Araj, Houmam H
Project Start
2008-03-01
Project End
2013-04-30
Budget Start
2012-03-01
Budget End
2013-04-30
Support Year
9
Fiscal Year
2012
Total Cost
$358,776
Indirect Cost
$121,176
Name
Indiana University Bloomington
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Sreenivasan, Vidhyapriya; Babinsky, Erin E; Wu, Yifei et al. (2016) Objective Measurement of Fusional Vergence Ranges and Heterophoria in Infants and Preschool Children. Invest Ophthalmol Vis Sci 57:2678-88
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2016) Vergence Adaptation to Short-Duration Stimuli in Early Childhood. Invest Ophthalmol Vis Sci 57:920-7
Seemiller, Eric S; Wang, Jingyun; Candy, T Rowan (2016) Sensitivity of vergence responses of 5- to 10-week-old human infants. J Vis 16:20
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2015) Near heterophoria in early childhood. Invest Ophthalmol Vis Sci 56:1406-15
Manh, Vivian; Chen, Angela M; Tarczy-Hornoch, Kristina et al. (2015) Accommodative performance of children with unilateral amblyopia. Invest Ophthalmol Vis Sci 56:1193-207
Barrett, Brendan T; Bradley, Arthur; Candy, T Rowan (2013) The relationship between anisometropia and amblyopia. Prog Retin Eye Res 36:120-58
Bharadwaj, Shrikant R; Sravani, N Geetha; Little, Julie-Anne et al. (2013) Empirical variability in the calibration of slope-based eccentric photorefraction. J Opt Soc Am A Opt Image Sci Vis 30:923-31
Babinsky, Erin; Candy, T Rowan (2013) Why do only some hyperopes become strabismic? Invest Ophthalmol Vis Sci 54:4941-55
Candy, T Rowan; Gray, Kathryn H; Hohenbary, Christy C et al. (2012) The accommodative lag of the young hyperopic patient. Invest Ophthalmol Vis Sci 53:143-9
Candy, T Rowan (2012) Which hyperopic patients are destined for trouble? J AAPOS 16:107-9

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