The postnatal development of both the optical and neural visual systems is dependent on visual experience. Visual experience can be defined by the information available in the retinal images in the two eyes. The goal of the proposed research is to understand how the visual system controls this visual experience with accommodation and vergence motor responses, in normal development, amblyopia and strabismus. There are four interrelated projects: i) To understand motor performance over extended periods of time, to test hypotheses related to current theories of the effects of integrated experience on activity-dependent processes. ii) To determine the cues used in generating accommodation and vergence motor responses during development, to test hypotheses related to cue redundancy and the development of strabismus and amblyopia. iii) To determine the role of accommodation and vergence in the management of strabismus and test hypotheses about the control of these motor responses after surgery. iv) To understand retinal visual experience during amblyopia therapy and its role in successful treatments.

Public Health Relevance

Normal development of both the optical and neural visual systems is dependent on visual experience. Visual experience can be defined by the information available in the images formed on the retina. The goal of the proposed research is to understand how the accommodation and vergence responses of infants and young children impact their visual experience and the role that these responses play in normal and abnormal development, specifically in the context of amblyopia and strabismus.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY014460-10
Application #
8455618
Study Section
Special Emphasis Panel (SPC)
Program Officer
Araj, Houmam H
Project Start
2002-12-01
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
10
Fiscal Year
2013
Total Cost
$365,120
Indirect Cost
$131,069
Name
Indiana University Bloomington
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Seemiller, Eric S; Port, Nicholas L; Candy, T Rowan (2018) The gaze stability of 4- to 10-week-old human infants. J Vis 18:15
Chen, Angela M; Manh, Vivian; Candy, T Rowan (2018) Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia. Invest Ophthalmol Vis Sci 59:2187-2196
Wu, Yifei; Thibos, Larry N; Candy, T Rowan (2018) Two-dimensional simulation of eccentric photorefraction images for ametropes: factors influencing the measurement. Ophthalmic Physiol Opt 38:432-446
Seemiller, Eric S; Cumming, Bruce G; Candy, T Rowan (2018) Human infants can generate vergence responses to retinal disparity by 5 to 10 weeks of age. J Vis 18:17
Troyer, Mary E; Sreenivasan, Vidhyapriya; Peper, T J et al. (2017) The heterophoria of 3-5 year old children as a function of viewing distance and target type. Ophthalmic Physiol Opt 37:7-15
Wu, Yifei; Sreenivasan, Vidhyapriya; Babinsky, Erin E et al. (2016) Adaptation of horizontal eye alignment in the presence of prism in young children. J Vis 16:6
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2016) Vergence Adaptation to Short-Duration Stimuli in Early Childhood. Invest Ophthalmol Vis Sci 57:920-7
Sreenivasan, Vidhyapriya; Babinsky, Erin E; Wu, Yifei et al. (2016) Objective Measurement of Fusional Vergence Ranges and Heterophoria in Infants and Preschool Children. Invest Ophthalmol Vis Sci 57:2678-88
Seemiller, Eric S; Wang, Jingyun; Candy, T Rowan (2016) Sensitivity of vergence responses of 5- to 10-week-old human infants. J Vis 16:20
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2015) Near heterophoria in early childhood. Invest Ophthalmol Vis Sci 56:1406-15

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