The postnatal development of both the optical and neural visual systems is dependent on visual experience. Visual experience can be defined by the information available in the retinal images in the two eyes. The goal of the proposed research is to understand how the visual system controls this visual experience with accommodation and vergence motor responses, in normal development, amblyopia and strabismus. There are four interrelated projects: i) To understand motor performance over extended periods of time, to test hypotheses related to current theories of the effects of integrated experience on activity-dependent processes. ii) To determine the cues used in generating accommodation and vergence motor responses during development, to test hypotheses related to cue redundancy and the development of strabismus and amblyopia. iii) To determine the role of accommodation and vergence in the management of strabismus and test hypotheses about the control of these motor responses after surgery. iv) To understand retinal visual experience during amblyopia therapy and its role in successful treatments.

Public Health Relevance

Normal development of both the optical and neural visual systems is dependent on visual experience. Visual experience can be defined by the information available in the images formed on the retina. The goal of the proposed research is to understand how the accommodation and vergence responses of infants and young children impact their visual experience and the role that these responses play in normal and abnormal development, specifically in the context of amblyopia and strabismus.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY014460-10
Application #
8455618
Study Section
Special Emphasis Panel (SPC)
Program Officer
Araj, Houmam H
Project Start
2002-12-01
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
10
Fiscal Year
2013
Total Cost
$365,120
Indirect Cost
$131,069
Name
Indiana University Bloomington
Department
None
Type
Schools of Optometry/Ophthalmol
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Barrett, Brendan T; Bradley, Arthur; Candy, T Rowan (2013) The relationship between anisometropia and amblyopia. Prog Retin Eye Res 36:120-58
Babinsky, Erin; Candy, T Rowan (2013) Why do only some hyperopes become strabismic? Invest Ophthalmol Vis Sci 54:4941-55
Bharadwaj, Shrikant R; Sravani, N Geetha; Little, Julie-Anne et al. (2013) Empirical variability in the calibration of slope-based eccentric photorefraction. J Opt Soc Am A Opt Image Sci Vis 30:923-31
Candy, T Rowan; Gray, Kathryn H; Hohenbary, Christy C et al. (2012) The accommodative lag of the young hyperopic patient. Invest Ophthalmol Vis Sci 53:143-9
Candy, T Rowan (2012) Which hyperopic patients are destined for trouble? J AAPOS 16:107-9
Bharadwaj, Shrikant R; Wang, Jingyun; Candy, T Rowan (2011) Pupil responses to near visual demand during human visual development. J Vis 11:6
Bharadwaj, Shrikant R; Candy, T Rowan (2011) The effect of lens-induced anisometropia on accommodation and vergence during human visual development. Invest Ophthalmol Vis Sci 52:3595-603
Candy, T Rowan; Mishoulam, Sylvia R; Nosofsky, Robert M et al. (2011) Adult discrimination performance for pediatric acuity test optotypes. Invest Ophthalmol Vis Sci 52:4307-13
Wang, Jingyun; Candy, T Rowan (2010) The sensitivity of the 2- to 4-month-old human infant accommodation system. Invest Ophthalmol Vis Sci 51:3309-17
Dobson, Velma; Candy, T Rowan; Hartmann, E Eugenie et al. (2009) Infant and child vision research: present status and future directions. Optom Vis Sci 86:559-60

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