While the effects of visual deprivation have been well studied in animal models, much less is known about the effects of blindness on human early visual pathways. Understanding the effects of visual deprivation on early visual pathways in humans is important for two reasons. First, a deeper understanding of the effects of blindness will prove increasingly important as new sight restoration procedures (such as retinal prosthetic implants, epithelial stem cell replacements, gene therapies and retinal transplants) become available over the next few decades. Second, blindness due to peripheral causes is an excellent model system for understanding prenatal, postnatal and adult cortical plasticity. We propose to use a combination of "state-of-the-art" MR imaging techniques to examine the effects of blindness on human sub-cortical and cortical visual pathways. Four subject groups will be compared: anophthalmic (born without eyes), non-anophthalmic congenitally blind, late blind and normally sighted control subjects. High resolution structural imaging will be used to measure changes in the size of the lateral geniculate nucleus and changes in the size and myelination patterns of area V1 as a consequence of early blindness. Probabilistic tractography will be used to measure the effects of early blindness on connections between the lateral geniculate nucleus and V1, and between V1 and the corpus callosum. Magnetic resonance spectroscopy will be used to examine the neurochemical effects of blindness on myelination processes and metabolic, cholinergic, and GABA-ergic pathways within blind individuals. Our inclusion of anophthalmic, early blind and late blind subjects will allow us to compare the effects of embryonic development, postnatal development, and adult visual deprivation on sub-cortical and cortical development in humans. This work is likely to have significance not only for understanding development of the human visual system, but also for understanding large-scale developmental sub-cortical and cortical plasticity in general.

Public Health Relevance

While the effects of visual deprivation have been well studied in animal models, much less is known about the effects of blindness on human early visual pathways. We propose to use a combination of state-of-the-art MR imaging techniques (high resolution structural imaging, probabilistic diffusion tractography, and magnetic resonance spectroscopy) to examine the effects of blindness on early stages of visual processing. This work is likely to have significance not only for our understanding of the development of the human visual system, but also for improving our general understanding of large scale sub-cortical and cortical plasticity.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY014645-09
Application #
8535155
Study Section
Special Emphasis Panel (ZRG1-IFCN-E (02))
Program Officer
Wiggs, Cheri
Project Start
2003-04-01
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
9
Fiscal Year
2013
Total Cost
$336,027
Indirect Cost
$95,186
Name
University of Washington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Jiang, Fang; Stecker, G Christopher; Boynton, Geoffrey M et al. (2016) Early Blindness Results in Developmental Plasticity for Auditory Motion Processing within Auditory and Occipital Cortex. Front Hum Neurosci 10:324
Bock, Andrew S; Binda, Paola; Benson, Noah C et al. (2015) Resting-State Retinotopic Organization in the Absence of Retinal Input and Visual Experience. J Neurosci 35:12366-82
Jiang, Fang; Beauchamp, Michael S; Fine, Ione (2015) Re-examining overlap between tactile and visual motion responses within hMT+ and STS. Neuroimage 119:187-96
Coullon, Gaelle S L; Emir, Uzay E; Fine, Ione et al. (2015) Neurochemical changes in the pericalcarine cortex in congenital blindness attributable to bilateral anophthalmia. J Neurophysiol 114:1725-33
Fine, Ione; Boynton, Geoffrey M (2015) Pulse trains to percepts: the challenge of creating a perceptually intelligible world with sight recovery technologies. Philos Trans R Soc Lond B Biol Sci 370:20140208
Thomas, Jessica M; Huber, Elizabeth; Stecker, G Christopher et al. (2015) Population receptive field estimates of human auditory cortex. Neuroimage 105:428-39
Huber, Elizabeth; Webster, Jason M; Brewer, Alyssa A et al. (2015) A lack of experience-dependent plasticity after more than a decade of recovered sight. Psychol Sci 26:393-401
Fine, Ione; Cepko, Connie L; Landy, Michael S (2015) Vision research special issue: Sight restoration: Prosthetics, optogenetics and gene therapy. Vision Res 111:115-23
Coullon, Gaelle S L; Jiang, Fang; Fine, Ione et al. (2015) Subcortical functional reorganization due to early blindness. J Neurophysiol 113:2889-99
Jiang, Fang; Stecker, G Christopher; Fine, Ione (2014) Auditory motion processing after early blindness. J Vis 14:4

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