Patients with HIV-disease have responded well to the highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss continues to occur despite elevated CD4 counts. In this grant we plan to assess and quantify retinal damage to the retinal nerve fiber layer (RNFL) and normal retinal tissue with the help of two non-invasive imaging techniques - scanning laser polarimetry (SLP) and optical coherence tomography (OCT). We will test two different hypotheses that might explain the vision loss - one is cytokine mediated optic neuropathy and the other is microvascular ischemia in the retina. The first specific aim of our study is to quantify RNFL defects by SLP, conventional OCT and high-resolution (HR) OCT in a cross-sectional and longitudinal study. RNFL defects are measured along a circumference around the optic nerve head in a manner analogous to studies in glaucoma research. The second specific aim is to quantify retinal defects throughout the posterior pole by HR-OCT in a cross-sectional and longitudinal study, as well. These retinal defects can occur throughout the retina and will be imaged by 3-D images. The third specific aim is correlate the RNFL and retinal defects detected with both imaging instruments with standard visual field function testing, short-wavelength automated perimetry and other structural and function data. Our research team encompasses a group of highly-qualified individuals with various expertise. Our team includes experts on retinal imaging, an expert in the study of HIV-related ocular complications, an expert in neurobehavioral research, and an expert on high-resolution optical coherence tomography.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY016323-04
Application #
7633212
Study Section
Special Emphasis Panel (ZRG1-AARR-A (03))
Program Officer
Shen, Grace L
Project Start
2006-06-01
Project End
2011-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
4
Fiscal Year
2009
Total Cost
$328,245
Indirect Cost
Name
University of California San Diego
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Ramkumar, Hema L; Nguyen, Brian; Bartsch, Dirk-Uwe et al. (2018) REDUCED GANGLION CELL VOLUME ON OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH GEOGRAPHIC ATROPHY. Retina 38:2159-2167
Bosse, Brandon; Damle, Samir; Akinin, Abraham et al. (2018) In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode-Based Retinal Prosthesis. Invest Ophthalmol Vis Sci 59:5885-5892
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Muftuoglu, Ilkay Kilic; Ramkumar, Hema L; Bartsch, Dirk-Uwe et al. (2018) QUANTITATIVE ANALYSIS OF THE INNER RETINAL LAYER THICKNESSES IN AGE-RELATED MACULAR DEGENERATION USING CORRECTED OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION. Retina 38:1478-1484
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Kilic Muftuoglu, Ilkay; Bartsch, Dirk-Uwe; Barteselli, Giulio et al. (2018) VISUALIZATION OF MACULAR PUCKER BY MULTICOLOR SCANNING LASER IMAGING. Retina 38:352-358
Muftuoglu, Ilkay Kilic; Gaber, Raouf; Bartsch, Dirk-Uwe et al. (2018) Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions. Graefes Arch Clin Exp Ophthalmol 256:643-649
Muftuoglu, Ilkay K; Alam, Mostafa; You, Qi Sheng et al. (2017) Reply. Retina 37:e110-e112
Bartsch, Dirk-Uwe; Muftuoglu, Ilkay K; Freeman, William R (2016) Laser Pointers Revisited. Retina 36:1611-3
Barteselli, Giulio; Bartsch, Dirk-Uwe; Weinreb, Robert N et al. (2016) REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography. Retina 36:1153-61

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