Patients with HIV-disease have responded well to the highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss continues to occur despite elevated CD4 counts. In this grant we plan to assess and quantify retinal damage to the retinal nerve fiber layer (RNFL) and normal retinal tissue with the help of two non-invasive imaging techniques - scanning laser polarimetry (SLP) and optical coherence tomography (OCT). We will test two different hypotheses that might explain the vision loss - one is cytokine mediated optic neuropathy and the other is microvascular ischemia in the retina. The first specific aim of our study is to quantify RNFL defects by SLP, conventional OCT and high-resolution (HR) OCT in a cross-sectional and longitudinal study. RNFL defects are measured along a circumference around the optic nerve head in a manner analogous to studies in glaucoma research. The second specific aim is to quantify retinal defects throughout the posterior pole by HR-OCT in a cross-sectional and longitudinal study, as well. These retinal defects can occur throughout the retina and will be imaged by 3-D images. The third specific aim is correlate the RNFL and retinal defects detected with both imaging instruments with standard visual field function testing, short-wavelength automated perimetry and other structural and function data. Our research team encompasses a group of highly-qualified individuals with various expertise. Our team includes experts on retinal imaging, an expert in the study of HIV-related ocular complications, an expert in neurobehavioral research, and an expert on high-resolution optical coherence tomography.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY016323-05
Application #
7860551
Study Section
Special Emphasis Panel (ZRG1-AARR-A (03))
Program Officer
Shen, Grace L
Project Start
2006-06-01
Project End
2011-09-29
Budget Start
2010-06-01
Budget End
2011-09-29
Support Year
5
Fiscal Year
2010
Total Cost
$327,490
Indirect Cost
Name
University of California San Diego
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Muftuoglu, Ilkay Kilic; Ramkumar, Hema L; Bartsch, Dirk-Uwe et al. (2017) QUANTITATIVE ANALYSIS OF THE INNER RETINAL LAYER THICKNESSES IN AGE-RELATED MACULAR DEGENERATION USING CORRECTED OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION. Retina :
Ramkumar, Hema L; Nguyen, Brian; Bartsch, Dirk-Uwe et al. (2017) REDUCED GANGLION CELL VOLUME ON OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH GEOGRAPHIC ATROPHY. Retina :
Bartsch, Dirk-Uwe; Muftuoglu, Ilkay K; Freeman, William R (2016) Laser Pointers Revisited. Retina 36:1611-3
Barteselli, Giulio; Bartsch, Dirk-Uwe; Weinreb, Robert N et al. (2016) REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography. Retina 36:1153-61
You, Qi Sheng; Bartsch, Dirk-Uwe G; Espina, Mark et al. (2016) REPRODUCIBILITY OF MACULAR PIGMENT OPTICAL DENSITY MEASUREMENT BY TWO-WAVELENGTH AUTOFLUORESCENCE IN A CLINICAL SETTING. Retina 36:1381-7
Hartmann, Kathrin I; Oster, Stephen F; Amini, Payam et al. (2015) SLO-Microperimetry in Wet Age-Related Macular Degeneration During Anti-VEGF Therapy. Ophthalmic Surg Lasers Imaging Retina 46:824-30
Bartsch, Dirk-Uwe; Kozak, Igor; Grant, Igor et al. (2015) Retinal Nerve Fiber and Optic Disc Morphology in Patients with Human Immunodeficiency Virus Using the Heidelberg Retina Tomography 3. PLoS One 10:e0133144
Arcinue, Cheryl A; Bartsch, Dirk-Uwe; El-Emam, Sharif Y et al. (2015) Retinal Thickening and Photoreceptor Loss in HIV Eyes without Retinitis. PLoS One 10:e0132996
Espina, Mark P; Arcinue, Cheryl A; Ma, Feiyan et al. (2015) ANALYSIS OF A CONFOCAL SCANNING LASER OPHTHALMOSCOPE NONCONTACT ULTRA-WIDE FIELD LENS SYSTEM IN RETINAL AND CHOROIDAL DISEASE. Retina 35:2664-8
Sahu, Bhubanananda; Chavali, Venkata R M; Alapati, Akhila et al. (2015) Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model. Mol Vis 21:273-84

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