Patients with HIV-disease continue to be treated with highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss and neurological loss continues to occur despite elevated CD4 counts. We have previously shown that we are able to visualize subtle retinal changes associated with healed cotton-wool spots (CWS) up to 16 years after the active phase. In this grant we plan to study the group of subjects that continue to exhibit neurological changes and retinal damage. Our hypothesis is that retinal damage is associated with neurological changes. Our first specific aim is to quantify retinal damage by high-resolution adaptive- optical corrected OCT. Our second specific aim is to develop a computer algorithm to map the defects associated with healed CWS. Our results have indicated that healed CWS demonstrate a characteristic restructuring of the retinal layers. This restructuring can be mapped in 3-D OCT images. The third specific aim is to correlate structural retinal defects with neurological markers collected by our collaborators at the UCSD's HIV Neurobehavioral Research Center. A possible correlation might help us by using retinal structural markers as indicators for neurological damage. Our team of collaborators includes experts on retinal imaging, computer processing, and neurobehavioral research.

Public Health Relevance

This grant will create a method of automatically mapping the presence of retinal damage associated with HIV infection. A high-resolution eye camera will be used to systematically image the back of the eye. The study will compare structural information to functional information to find a possible correlation.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY016323-07
Application #
8331552
Study Section
Special Emphasis Panel (ZRG1-AARR-K (03))
Program Officer
Mckie, George Ann
Project Start
2004-12-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
7
Fiscal Year
2012
Total Cost
$429,845
Indirect Cost
$108,057
Name
University of California San Diego
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Barteselli, Giulio; Bartsch, Dirk-Uwe; Weinreb, Robert N et al. (2016) REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography. Retina 36:1153-61
Bartsch, Dirk-Uwe; Muftuoglu, Ilkay K; Freeman, William R (2016) Laser Pointers Revisited. Retina 36:1611-3
You, Qi Sheng; Bartsch, Dirk-Uwe G; Espina, Mark et al. (2016) REPRODUCIBILITY OF MACULAR PIGMENT OPTICAL DENSITY MEASUREMENT BY TWO-WAVELENGTH AUTOFLUORESCENCE IN A CLINICAL SETTING. Retina 36:1381-7
Arcinue, Cheryl A; Bartsch, Dirk-Uwe; El-Emam, Sharif Y et al. (2015) Retinal Thickening and Photoreceptor Loss in HIV Eyes without Retinitis. PLoS One 10:e0132996
Hartmann, Kathrin I; Oster, Stephen F; Amini, Payam et al. (2015) SLO-Microperimetry in Wet Age-Related Macular Degeneration During Anti-VEGF Therapy. Ophthalmic Surg Lasers Imaging Retina 46:824-30
Bartsch, Dirk-Uwe; Kozak, Igor; Grant, Igor et al. (2015) Retinal Nerve Fiber and Optic Disc Morphology in Patients with Human Immunodeficiency Virus Using the Heidelberg Retina Tomography 3. PLoS One 10:e0133144
Espina, Mark P; Arcinue, Cheryl A; Ma, Feiyan et al. (2015) ANALYSIS OF A CONFOCAL SCANNING LASER OPHTHALMOSCOPE NONCONTACT ULTRA-WIDE FIELD LENS SYSTEM IN RETINAL AND CHOROIDAL DISEASE. Retina 35:2664-8
Barteselli, Giulio; Chhablani, Jay; Gomez, Maria Laura et al. (2014) Visual function assessment in simulated real-life situations in HIV-infected subjects. PLoS One 9:e97023
Hartmann, Kathrin I; Schuster, Alexander K; Bartsch, Dirk-Uwe et al. (2014) Restoration of retinal layers after epiretinal membrane peeling. Retina 34:647-54
Barteselli, G; Gomez, M L; Doede, A L et al. (2014) Visual function assessment in simulated real-life situations in patients with age-related macular degeneration compared to normal subjects. Eye (Lond) 28:1231-8

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