Patients with HIV-disease continue to be treated with highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss and neurological loss continues to occur despite elevated CD4 counts. We have previously shown that we are able to visualize subtle retinal changes associated with healed cotton-wool spots (CWS) up to 16 years after the active phase. In this grant we plan to study the group of subjects that continue to exhibit neurological changes and retinal damage. Our hypothesis is that retinal damage is associated with neurological changes. Our first specific aim is to quantify retinal damage by high-resolution adaptive- optical corrected OCT. Our second specific aim is to develop a computer algorithm to map the defects associated with healed CWS. Our results have indicated that healed CWS demonstrate a characteristic restructuring of the retinal layers. This restructuring can be mapped in 3-D OCT images. The third specific aim is to correlate structural retinal defects with neurological markers collected by our collaborators at the UCSD's HIV Neurobehavioral Research Center. A possible correlation might help us by using retinal structural markers as indicators for neurological damage. Our team of collaborators includes experts on retinal imaging, computer processing, and neurobehavioral research.

Public Health Relevance

This grant will create a method of automatically mapping the presence of retinal damage associated with HIV infection. A high-resolution eye camera will be used to systematically image the back of the eye. The study will compare structural information to functional information to find a possible correlation.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Study Section
Special Emphasis Panel (ZRG1-AARR-K (03))
Program Officer
Mckie, George Ann
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University of California San Diego
Schools of Medicine
La Jolla
United States
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Barteselli, Giulio; Chhablani, Jay; Gomez, Maria Laura et al. (2014) Visual function assessment in simulated real-life situations in HIV-infected subjects. PLoS One 9:e97023
Barteselli, G; Gomez, M L; Doede, A L et al. (2014) Visual function assessment in simulated real-life situations in patients with age-related macular degeneration compared to normal subjects. Eye (Lond) 28:1231-8
Hartmann, Kathrin I; Schuster, Alexander K; Bartsch, Dirk-Uwe et al. (2014) Restoration of retinal layers after epiretinal membrane peeling. Retina 34:647-54
Barteselli, Giulio; Bartsch, Dirk-Uwe; Freeman, William R (2013) Combined depth imaging using optical coherence tomography as a novel imaging technique to visualize vitreoretinal choroidal structures. Retina 33:247-8
Barteselli, Giulio; Chhablani, Jay; Lee, Su Na et al. (2013) Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography. Retina 33:1574-83
Barteselli, Giulio; Bartsch, Dirk-Uwe; Viola, Francesco et al. (2013) Accuracy of the Heidelberg Spectralis in the alignment between near-infrared image and tomographic scan in a model eye: a multicenter study. Am J Ophthalmol 156:588-92
Kozak, Igor; Sasik, Roman; Freeman, William R et al. (2013) A degenerative retinal process in HIV-associated non-infectious retinopathy. PLoS One 8:e74712
Chhablani, Jay; Bartsch, Dirk-Uwe; Cheng, Lingyun et al. (2013) Segmental reproducibility of retinal blood flow velocity measurements using retinal function imager. Graefes Arch Clin Exp Ophthalmol 251:2665-70
Hartmann, Kathrin I; Bartsch, Dirk-Uwe G; Cheng, Lingyun et al. (2011) Scanning laser ophthalmoscope imaging stabilized microperimetry in dry age-related macular degeneration. Retina 31:1323-31
Kim, Jae Suk; Maheshwary, Anjali S; Bartsch, Dirk-Uwe G et al. (2011) The microperimetry of resolved cotton-wool spots in eyes of patients with hypertension and diabetes mellitus. Arch Ophthalmol 129:879-84

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