A hallmark of primary visual cortex is its organization into maps of visual space, orientation and ocular dominance. Despite remarkable advances in our ability to measure the structure of cortical maps and their mutual relationships, many important questions remain unanswered. How do these maps develop? Why are maps missing in some species? What role do maps play, if any, in cortical computation? The central goal of our research is to seek answers to these fundamental questions of cortical development, organization and function that have eluded us for decades. Our working hypothesis is that the blueprint for the formation of simple-cell receptive fields and orientation maps in primary visual cortex is encoded in the spatial layout of retinal ganglion cell (RGC) mosaics. To test the idea we will analyze the spatial statistics of RGC mosaics, reconstruct the retinal input to given orientation domains, and test the micro-organization of cortical maps. If the these ideas are confirmed, they can offer a definitive account for the origin of orientation maps in primary visua cortex and, more broadly, profoundly influence the way we conceive of cortical maps, their development and function.

Public Health Relevance

We do not yet know how the brain develops the myriad of connections upon which normal brain activity and behavior depend upon. To better understand developmental disorders of the central nervous system, we need to elucidate how the brain wires itself under normal conditions. The proposed studies address this important question for the early stages of visual processing by investigating how the eyes establish connections to the visual cortex.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY018322-07
Application #
8664851
Study Section
Special Emphasis Panel (SPC)
Program Officer
Steinmetz, Michael A
Project Start
2007-09-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
7
Fiscal Year
2014
Total Cost
$540,246
Indirect Cost
$131,288
Name
University of California Los Angeles
Department
Neurosciences
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Paik, Se-Bum; Ringach, Dario L (2012) Link between orientation and retinotopic maps in primary visual cortex. Proc Natl Acad Sci U S A 109:7091-6
Paik, Se-Bum; Ringach, Dario L (2011) Retinal origin of orientation maps in visual cortex. Nat Neurosci 14:919-25
Xing, Dajun; Ringach, Dario L; Hawken, Michael J et al. (2011) Untuned suppression makes a major contribution to the enhancement of orientation selectivity in macaque v1. J Neurosci 31:15972-82
Theobald, Jamie C; Ringach, Dario L; Frye, Mark A (2010) Dynamics of optomotor responses in Drosophila to perturbations in optic flow. J Exp Biol 213:1366-75
Theobald, Jamie C; Ringach, Dario L; Frye, Mark A (2010) Visual stabilization dynamics are enhanced by standing flight velocity. Biol Lett 6:410-3
Tavassoli, Abtine; Ringach, Dario L (2010) When your eyes see more than you do. Curr Biol 20:R93-4
Benucci, Andrea; Ringach, Dario L; Carandini, Matteo (2009) Coding of stimulus sequences by population responses in visual cortex. Nat Neurosci 12:1317-24
Tavassoli, Abtine; Ringach, Dario L (2009) Dynamics of smooth pursuit maintenance. J Neurophysiol 102:110-8
Nauhaus, Ian; Busse, Laura; Carandini, Matteo et al. (2009) Stimulus contrast modulates functional connectivity in visual cortex. Nat Neurosci 12:70-6
Katzner, Steffen; Nauhaus, Ian; Benucci, Andrea et al. (2009) Local origin of field potentials in visual cortex. Neuron 61:35-41

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