Age related macular degeneration (AMD) is one of the primary causes of blindness in the U.S. A wealth of powerful new treatments, especially anti-VEGF agents, have recently become available to restore visual function in choroidal neovascularization (CNV), the most severe form of AMD. The risk of ocular adverse events increases with repeated intravitreal treatment injections. Ideally a patient-specific dosing strategy with the minimally necessary number of anti-VEGF injections would be employed. This study will address which patient-specific properties of the intra- and sub-retinal fluid, cysts, and retinal layers of the macula (obtained from 3D spectral domain optical coherence tomography or OCT) (i) are associated with individual response to anti-VGEF treatment, and (ii) can predict proper treatment timing and response. The main hypothesis motivating the proposed research is that a model of retinal response to initial anti-VEGF treatment for CNV, based on quantitative 3D OCT-derived measures, can predict the timing of retreatment. We have identified the following specific aims:
Aim 1 : Further refine and validate a comprehensive set of analysis methods and approaches for 3D spectral OCT image analysis in the presence of wet AMD pathology (Symptomatic Exudate Associated Derangements or SEADs) and assess its performance by comparison to expert analyses.
Aim 2 : Determine associations between standard 2D Spectralis OCT clinical readings from retinal specialists and quantitative SEAD- and layer-derived measures from 3D Cirrus OCT.
Aim 3 : Determine how well the quantitative SEAD- and layer-derived measures from 3D OCT predict the patient-specific outcome parameters in response to post-induction anti-VEGF treatment in patients with CNV, in order to predict the timing of retreatment. The work will be performed prospectively in in-vivo spectral-domain OCT images acquired during the course of CNV disease treatment. We will repeatedly image 200 patients with choroidal neovascularization before and during treatment and during the 1-year follow-up phase.
Three dimensional spectral OCT imaging provides a wealth of information about the morphology and tissue characteristics of human retinal. We propose to study structural and functional relationships of the macular intraretinal layers using this new 3-D OCT imaging device and relate the information about patient-specific retinal composition and structure with treatment outcome in age-related macular degeneration. This study has potentially important consequences for image guided treatment of this blindness-causing disease.
|Zarei, Kasra; Scheetz, Todd E; Christopher, Mark et al. (2016) Automated Axon Counting in Rodent Optic Nerve Sections with AxonJ. Sci Rep 6:26559|
|Sohn, Elliott H; van Dijk, Hille W; Jiao, Chunhua et al. (2016) Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci U S A 113:E2655-64|
|Christopher, Mark; AbrÃ moff, Michael D; Tang, Li et al. (2015) Stereo Photo Measured ONH Shape Predicts Development of POAG in Subjects With Ocular Hypertension. Invest Ophthalmol Vis Sci 56:4470-9|
|BogunoviÄ‡, Hrvoje; Kwon, Young H; Rashid, Adnan et al. (2015) Relationships of retinal structure and humphrey 24-2 visual field thresholds in patients with glaucoma. Invest Ophthalmol Vis Sci 56:259-71|
|Chen, Haoyu; Chen, Xinjian; Qiu, Zhiqiao et al. (2015) Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion. Sci Rep 5:9269|
|Bogunovic, Hrvoje; Sonka, Milan; Kwon, Young H et al. (2014) Multi-surface and multi-field co-segmentation of 3-D retinal optical coherence tomography. IEEE Trans Med Imaging 33:2242-53|
|AbrÃ moff, Michael D; Wu, Xiaodong; Lee, Kyungmoo et al. (2014) Subvoxel accurate graph search using non-Euclidean graph space. PLoS One 9:e107763|
|Zhang, Li; Sonka, Milan; Folk, James C et al. (2014) Quantifying disrupted outer retinal-subretinal layer in SD-OCT images in choroidal neovascularization. Invest Ophthalmol Vis Sci 55:2329-35|
|Longmuir, Susannah Q; Oral, Resmiye; Walz, Amy E et al. (2014) Quantitative measurement of retinal hemorrhages in suspected victims of child abuse. J AAPOS 18:529-33|
|Springelkamp, HenriÃ«t; Lee, Kyungmoo; Wolfs, Roger C W et al. (2014) Population-based evaluation of retinal nerve fiber layer, retinal ganglion cell layer, and inner plexiform layer as a diagnostic tool for glaucoma. Invest Ophthalmol Vis Sci 55:8428-38|
Showing the most recent 10 out of 43 publications