We study visual attention because of its importance in visual perception. Behavioral paradigms, such as change blindness, have shown us that while we think we perceive the whole visual world, we only take away information about regions or objects that we have attended. Because visual attention is a foundation of visual perception, it underlies most of our interactions with the perceived world - both our physical interactions and more intellectual interactions, such as learning and memory. This is highlighted in patients with parietal lesions - the difficulty they have in interacting with the world leads to significantly loger hospital stays than many other stroke patients, incurring greater costs for family members and the community as a whole. Thus, increasing our understanding of the mechanisms underlying the guidance of attention is important as a health issue in addition to being critical in allowing s to gain a deeper insight into how the brain makes decisions based on both external and cognitive inputs and, in the long run, insight into the mechanisms underlying visual perception itself. In the previous grant, we focused on the role of the lateral intraparietal area (LIP), and showed how the activity in LIP can be used to guide attention. The results from that study suggested that the information in LIP needs to be processed in a specific way before it can be used to guide eye movements. In this study, we build on this work by testing predictions based on the hypothesis that that there is a reciprocal connection from the frontal eye field (FEF) to LIP, in which a subset of neurons in FEF provides top-down input to LIP and a subset of neurons in FEF receives processed information from LIP. We do so by examining the responses of neurons in FEF and identifying them as projecting to LIP or receiving projections from LIP.
In aim 1, we test the prediction that FEF neurons encode signals which could be the genesis of top-down responses seen in LIP. We will show that neurons that project directly or indirectly back to LIP have early responses which contain component signals that are adequate and appropriate to explain top-down effects in LIP. These responses often begin before an eye movement is made and are often overridden by a feed-forward connection 150-200 ms after the eye stops moving.
In aim 2, we test the prediction that later responses in FEF neurons are consistent with the normalized output of responses seen in LIP. We do this by comparing the responses in FEF to the behavior and estimates of stimulus value. Based on the responses seen in earlier cortical areas, we have explicit predictions about how neurons that receive this information should behave. Overall, these experiments are aimed at showing how the LIP-FEF circuit guides the allocation of attention and, in doing so, will give us a greater understanding o how neural circuits process information in general sensori-motor transformations.

Public Health Relevance

Visual attention is important in everyday life; without it we cannot interact or learn from the visual world and patients with parietal lesions have deficits in visual attention, which greatly increases the length of hospital stays after parietal strokes compared to other strokes, increasing the emotional and financial costs of these strokes on family and society. The results from this study help us understand the way information from parietal cortex is processed to drive the allocation of visual attention. A greater understanding o these processes may aid in the development of pharmacological or behavioral methods to combat these problems.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
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Flanders, Martha C
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Arcizet, Fabrice; Mirpour, Koorosh; Foster, Daniel J et al. (2018) Activity in LIP, But not V4, Matches Performance When Attention is Spread. Cereb Cortex 28:4195-4209
Mirpour, Koorosh; Bolandnazar, Zeinab; Bisley, James W (2018) Suppression of frontal eye field neuronal responses with maintained fixation. Proc Natl Acad Sci U S A 115:804-809
Ong, Wei Song; Mirpour, Koorosh; Bisley, James W (2017) Object comparison in the lateral intraparietal area. J Neurophysiol 118:2458-2469
Mirpour, Koorosh; Bisley, James W (2016) Remapping, Spatial Stability, and Temporal Continuity: From the Pre-Saccadic to Postsaccadic Representation of Visual Space in LIP. Cereb Cortex 26:3183-95
Arcizet, Fabrice; Mirpour, Koorosh; Foster, Daniel J et al. (2015) LIP activity in the interstimulus interval of a change detection task biases the behavioral response. J Neurophysiol 114:2637-48
Zelinsky, Gregory J; Bisley, James W (2015) The what, where, and why of priority maps and their interactions with visual working memory. Ann N Y Acad Sci 1339:154-64
Mirpour, Koorosh; Bisley, James W (2013) Evidence for differential top-down and bottom-up suppression in posterior parietal cortex. Philos Trans R Soc Lond B Biol Sci 368:20130069
Mirpour, Koorosh; Bisley, James W (2012) Anticipatory remapping of attentional priority across the entire visual field. J Neurosci 32:16449-57
Shariat Torbaghan, Solmaz; Yazdi, Daniel; Mirpour, Koorosh et al. (2012) Inhibition of return in a visual foraging task in non-human subjects. Vision Res 74:2-9
Bisley, James W; Mirpour, Koorosh; Arcizet, Fabrice et al. (2011) The role of the lateral intraparietal area in orienting attention and its implications for visual search. Eur J Neurosci 33:1982-90

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