Visual cortex is the site at which dramatic transformations in neuronal receptive field properties - and thus the representation of the visual world - occur. One important transformation is the integration of inputs from the right and left eyes (binocularity), which provides the basis for the representation of the visual world in three dimensions. The excitatory input that individual cortical neurons receive from the visual thalamus is segregated into right and left eye channels. While it is clear that visual cortex is the site at which these two streams of information converge for the first time, the roles that afferent excitation, cortical inhibition and spike threshold all play in creating a three- dimensional representation - stereo vision - are as yet unknown. Using whole cell recordings in vivo, I will investigate the emergence of binocularity and the contributions of these three mechanisms. The development of stereovision is sensitive to the visual environment: disruptions early in life, such as eye misalignment (strabismus), lead to persistent stereo deficits. Early strabismus causes cortical neurons to become highly monocular in their spiking response profiles. The effect of strabismus on the inputs to the cortical neurons is unknown. I will examine whether latent inputs exist in strabismic animals, which will allow me to determine if the changes in cortical cell responses are due to an anatomical reorganization of afferents or a physiological modulation that leaves latent inputs intact and potentially recoverable.

Public Health Relevance

Visual cortex is the site at which inputs from the right and left eyes are first integrated to provide a basis for the representation of the visual world in three dimensions (stereo vision). Proper stereo vision is disrupted by a difference in acuity between the two eyes (anisometropia) or misaligned eyes (strabismus) occurring during development. By understanding the mechanisms underlying both normal and abnormal visual function, we will gain insight into how normal vision may be restored in patients with related visual deficits.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY019288-04
Application #
8204644
Study Section
Central Visual Processing Study Section (CVP)
Program Officer
Steinmetz, Michael A
Project Start
2008-12-01
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2013-11-30
Support Year
4
Fiscal Year
2012
Total Cost
$356,210
Indirect Cost
$118,610
Name
University of Texas Austin
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
Mitchell, Jude F; Priebe, Nicholas J; Miller, Cory T (2015) Motion dependence of smooth pursuit eye movements in the marmoset. J Neurophysiol 113:3954-60
Scholl, Benjamin; Pattadkal, Jagruti J; Dilly, Geoffrey A et al. (2015) Local Integration Accounts for Weak Selectivity of Mouse Neocortical Parvalbumin Interneurons. Neuron 87:424-36
Scholl, Benjamin; Andoni, Sari; Priebe, Nicholas J (2015) Functional characterization of spikelet activity in the primary visual cortex. J Physiol 593:4979-94
Priebe, Nicholas J; McGee, Aaron W (2014) Mouse vision as a gateway for understanding how experience shapes neural circuits. Front Neural Circuits 8:123
Tan, Andrew Y Y; Chen, Yuzhi; Scholl, Benjamin et al. (2014) Sensory stimulation shifts visual cortex from synchronous to asynchronous states. Nature 509:226-9
Scholl, Benjamin; Tan, Andrew Y Y; Priebe, Nicholas J (2013) Strabismus disrupts binocular synaptic integration in primary visual cortex. J Neurosci 33:17108-22
Scholl, Benjamin; Burge, Johannes; Priebe, Nicholas J (2013) Binocular integration and disparity selectivity in mouse primary visual cortex. J Neurophysiol 109:3013-24
Tan, A Y Y; Andoni, S; Priebe, N J (2013) A spontaneous state of weakly correlated synaptic excitation and inhibition in visual cortex. Neuroscience 247:364-75
Scholl, Benjamin; Tan, Andrew Y Y; Corey, Joseph et al. (2013) Emergence of orientation selectivity in the Mammalian visual pathway. J Neurosci 33:10616-24
Priebe, Nicholas J; Ferster, David (2012) Mechanisms of neuronal computation in mammalian visual cortex. Neuron 75:194-208

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