Corneoscleral biomechanical properties may influence the characteristics of short-term IOP elevations, and thus play an important role in an individual's susceptibility to glaucoma. Our hypotheses are: (a) eyes with certain corneoscleral biomechanical properties (i.e., low stiffness) are more capable of damping IOP (i.e., smaller, slower, and/or shorter elevations), and (b) these corneoscleral biomechanical properties are affected by aging processes resulting in reduced capability to dampen IOP.
The specific aims are:
Aim 1 : To test the prediction that corneoscleral biomechanical properties affect short-term, dynamic IOP variations. We will examine in enucleated canine globes the influence of the natural variance or experimentally altered corneoscleral properties on the parameters of IOP elevations.
Aim 2 : To test the prediction that age-associated differences in corneoscleral biomechanical properties are correlated with the eye's ability to dampen IOP. We will examine whether there are age-related differences in physiologic, short- term IOP dynamics in human eyes. We will then investigate whether the age-associated differences in IOP parameters can be explained by the age-associated differences in the corneoscleral biomechanical properties. A novel ultrasonic technique will be used to non-invasively measure corneal properties in the human eye, establishing feasibility for future in vivo assessment and monitoring of corneoscleral properties. Significance: The proposed studies will detail the influences of the biomechanical characteristics of the corneoscleral shell on short-term IOP elevations, which will lead to the discovery of new measurable and modifiable glaucoma susceptibility factors that will improve clinical management of glaucoma.

Public Health Relevance

Elevated intraocular pressure (IOP) is a primary risk factor for glaucoma. This study will investigate how corneoscleral biomechanical properties influence the characteristics of short-term IOP elevations, leading to the identification of new measurable indices for glaucoma susceptibility.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Anterior Eye Disease Study Section (AED)
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Agarwal, Neeraj
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Ohio State University
Engineering (All Types)
Schools of Engineering
United States
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Clayson, Keyton; Pan, Xueliang; Pavlatos, Elias et al. (2017) Corneoscleral stiffening increases IOP spike magnitudes during rapid microvolumetric change in the eye. Exp Eye Res 165:29-34
Pavlatos, Elias; Perez, Benjamin Cruz; Morris, Hugh J et al. (2016) Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking. J Biomech Eng 138:021015
Cruz Perez, Benjamin; Pavlatos, Elias; Morris, Hugh J et al. (2016) Mapping 3D Strains with Ultrasound Speckle Tracking: Method Validation and Initial Results in Porcine Scleral Inflation. Ann Biomed Eng 44:2302-12
Palko, Joel R; Morris, Hugh J; Pan, Xueliang et al. (2016) Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation. PLoS One 11:e0156466
Boote, Craig; Palko, Joel R; Sorensen, Thomas et al. (2016) Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Mol Vis 22:503-17
Cruz Perez, Benjamin; Tang, Junhua; Morris, Hugh J et al. (2014) Biaxial mechanical testing of posterior sclera using high-resolution ultrasound speckle tracking for strain measurements. J Biomech 47:1151-6
Palko, Joel R; Tang, Junhua; Cruz Perez, Benjamin et al. (2014) Spatially heterogeneous corneal mechanical responses before and after riboflavin-ultraviolet-A crosslinking. J Cataract Refract Surg 40:1021-31
Perez, Benjamin Cruz; Morris, Hugh J; Hart, Richard T et al. (2013) Finite element modeling of the viscoelastic responses of the eye during microvolumetric changes. J Biomed Sci Eng 6:29-37
Morris, Hugh J; Tang, Junhua; Cruz Perez, Benjamin et al. (2013) Correlation between biomechanical responses of posterior sclera and IOP elevations during micro intraocular volume change. Invest Ophthalmol Vis Sci 54:7215-22
Palko, Joel R; Iwabe, Simone; Pan, Xueliang et al. (2013) Biomechanical properties and correlation with collagen solubility profile in the posterior sclera of canine eyes with an ADAMTS10 mutation. Invest Ophthalmol Vis Sci 54:2685-95

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