Single neuron neurophysiology has identified mechanisms of optic flow analysis in macaque dorsal extrastriate cortex (Duffy 2004). We have shown that optic flow perceptual deficits are associated with navigational impairments in aging and Alzheimer's disease (AD) (O'Brien 2001) (Mapstone 2010). Recently, we linked these lines of research by recording human optic flow event related potentials (ERPs), finding that they are highly correlated with perceptual and navigational impairments in aging and AD (Kavcic 2006) (Fernandez 2007). We have now recorded optic flow ERPs in monkeys, creating an opportunity to relate ERPs to the growing understanding of the cellular neurophysiology underlying visual motion processing. These efforts will elucidate the cortical mechanisms of optic flow analysis and its decline in aging and AD. We hypothesize that components of optic flow ERPs are specifically linked to the effects of bottom-up dorsal stream visual motion processing, and top-down attention and task related mechanisms thought to originate in posterior parietal (PPC) and dorso-lateral prefrontal (DLPFC) cortices. We will test this hypothesis in studies of monkeys viewing sequential optic flow stimuli during a memory guided saccade task. These studies will integrate the recording of single neurons in cortical area MSTd with the recording of LFPs in STS (superior temporal sulcus), PPC, and DLPFC, and with the recording of ERPs in a full cranial array. We will take three parallel approaches to probing the cortico-cortical interactions that link optic flow analysis to behavioral task demands and ERPs. First, we will analyze the co-variation in the responses of single neurons, LFPs, and ERPs to understanding the neurophysiological foundations of ERP components. Second, we will use age-related variation in ERP components to test for correlated variation in single neuron and LFP responses. Third, we will use pharmacological reversible inactivation to establish relations between specific cortical areas, ERP components, and the underlying neurophysiological response mechanisms. Understanding the neural mechanisms of visual motion processing, and its relationship to age-related changes in behavior, will promote the detection and amelioration of navigational impairments in aging and AD.

Public Health Relevance

Neurons in monkey dorsal extrastriate cortex process the visual motion in optic flow to support navigation. Navigational impairments in aging and Alzheimer's disease (AD) are associated with deficits in optic flow perception and changes in both sensory and attentional components of optic flow cortical evoked responses. We will now combine the recording of single neuron responses, local field potentials, and event related potentials in monkeys engaged in an optic flow related behavioral task. Our goal is to elucidate the origin and function of sensory and attentional responses to optic flow. These studies will identify the neural mechanisms underlying the debilitating navigational impairments that limit functional independence in aging and AD.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY022062-03
Application #
8710231
Study Section
Cognition and Perception Study Section (CP)
Program Officer
Steinmetz, Michael A
Project Start
2012-09-01
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
3
Fiscal Year
2014
Total Cost
$526,686
Indirect Cost
$185,789
Name
University of Rochester
Department
Neurology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Jacob, Michael S; Duffy, Charles J (2014) Might cortical hyper-responsiveness in aging contribute to Alzheimer's disease? PLoS One 9:e105962
Fernandez, Roberto; Monacelli, Anthony; Duffy, Charles J (2013) Visual motion event related potentials distinguish aging and Alzheimer's disease. J Alzheimers Dis 36:177-83