The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma and other diseases. Currently, there is no reliable method to perform measurements of corneal structural properties in vivo. Here we will develop a novel method for the topographical assessment of corneal elastic properties that could potentially be used for routine clinical diagnosis and monitoring of treatment. This method will take advantage of localized pulsed-air stimulation to generate microscopic pressure waves within the cornea and use phase-sensitive swept-source optical coherence tomography to detect and analyze the resultant pressure wave propagation within the cornea to reconstruct volumetric biomechanical properties of this tissue. Our long-term objectives are to use the coordinated talents of this research team to produce novel elasticity imaging instrumentation/methods that can extend our current understanding of the basic principles of tissue biomechanics and apply this knowledge to clinically relevant problems in ocular disease.

Public Health Relevance

This proposal will develop novel technology and methods for noninvasive reconstruction of biomechanical properties of the cornea. Development of such a technique would significantly advance our understanding of the corneal disorders, allow developing novel clinical therapies and interventions, and improve outcome of current surgical interventions including corneal refractive surgery.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY022362-01
Application #
8272279
Study Section
Special Emphasis Panel (ZRG1-NT-L (09))
Program Officer
Wiggs, Cheri
Project Start
2012-06-01
Project End
2015-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$434,468
Indirect Cost
$104,315
Name
University of Houston
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
036837920
City
Houston
State
TX
Country
United States
Zip Code
77204
Han, Zhaolong; Li, Jiasong; Singh, Manmohan et al. (2017) Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model. J Mech Behav Biomed Mater 66:87-94
Lan, Gongpu; Singh, Manmohan; Larin, Kirill V et al. (2017) Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity for dynamic elastography. Biomed Opt Express 8:5253-5266
Singh, Manmohan; Li, Jiasong; Han, Zhaolong et al. (2017) Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography. Biomed Opt Express 8:349-366
Larin, Kirill V; Sampson, David D (2017) Optical coherence elastography - OCT at work in tissue biomechanics [Invited]. Biomed Opt Express 8:1172-1202
Singh, Manmohan; Li, Jiasong; Vantipalli, Srilatha et al. (2017) Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking. J Biomed Opt 22:91504
Singh, Manmohan; Han, Zhaolong; Nair, Achuth et al. (2017) Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument. J Biomed Opt 22:20502
Liu, Chih-Hao; Schill, Alexander; Raghunathan, Raksha et al. (2017) Ultra-fast line-field low coherence holographic elastography using spatial phase shifting. Biomed Opt Express 8:993-1004
Du, Yong; Liu, Chih-Hao; Lei, Ling et al. (2016) Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography. J Biomed Opt 21:46002
Singh, Manmohan; Li, Jiasong; Han, Zhaolong et al. (2016) Investigating Elastic Anisotropy of the Porcine Cornea as a Function of Intraocular Pressure With Optical Coherence Elastography. J Refract Surg 32:562-7
Singh, Manmohan; Li, Jiasong; Han, Zhaolong et al. (2016) Evaluating the Effects of Riboflavin/UV-A and Rose-Bengal/Green Light Cross-Linking of the Rabbit Cornea by Noncontact Optical Coherence Elastography. Invest Ophthalmol Vis Sci 57:OCT112-20

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