To continue study of biologically related alkylating agents. Investigations will include 1H, 13C and 17O nuclear magnetic resonance spectroscopic, as well as X-ray structural studies of carbocationic, as well as oxonium and carboxonium ion type alkylating agents. Novel ionic alkylating agents will be prepared and studied, including their formation mechanism. Electrophilic hydroxylation and epoxidation reactions of hydrocarbons will be continued under stable ion conditions. Alkylation reactions will also be studied under solid superacidic catalytic conditions capable of mimicking enzymatic systems. To prepare needed compounds and intermediates, continued study of new synthetic methods and reactions will also be continued.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM024832-08
Application #
3272553
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1978-07-01
Project End
1988-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033