Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM030054-04S1
Application #
3277692
Study Section
(SSS)
Project Start
1982-04-01
Project End
1988-01-31
Budget Start
1987-04-01
Budget End
1988-01-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Lomnitz, Jason G; Savageau, Michael A (2016) Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems. Front Genet 7:118
Lomnitz, Jason G; Savageau, Michael A (2016) Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems. Sci Rep 6:32375
Fasani, Rick A; Savageau, Michael A (2015) Unrelated toxin-antitoxin systems cooperate to induce persistence. J R Soc Interface 12:20150130
Tolla, Dean A; Kiley, Patricia J; Lomnitz, Jason G et al. (2015) Design principles of a conditional futile cycle exploited for regulation. Mol Biosyst 11:1841-9
Lomnitz, Jason G; Savageau, Michael A (2015) Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire. NPJ Syst Biol Appl 1:
Lomnitz, Jason G; Savageau, Michael A (2014) Strategy revealing phenotypic differences among synthetic oscillator designs. ACS Synth Biol 3:686-701
Fasani, Rick A; Savageau, Michael A (2014) Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. Mol Biol Evol 31:2865-78
Fasani, Rick A; Savageau, Michael A (2013) Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proc Natl Acad Sci U S A 110:E2528-37
Williams, Kristen; Savageau, Michael A; Blumenthal, Robert M (2013) A bistable hysteretic switch in an activator-repressor regulated restriction-modification system. Nucleic Acids Res 41:6045-57
Lomnitz, Jason G; Savageau, Michael A (2013) Phenotypic deconstruction of gene circuitry. Chaos 23:025108

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