Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM031847-13
Application #
2176344
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1983-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Ye, Xiang; Mayne, Leland; Kan, Zhong-Yuan et al. (2018) Folding of maltose binding protein outside of and in GroEL. Proc Natl Acad Sci U S A 115:519-524
Nguyen, David; Mayne, Leland; Phillips, Michael C et al. (2018) Reference Parameters for Protein Hydrogen Exchange Rates. J Am Soc Mass Spectrom 29:1936-1939
Tischer, Alexander; Machha, Venkata R; Frontroth, Juan P et al. (2017) Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping. J Mol Biol 429:2161-2177
Chetty, Palaniappan S; Mayne, Leland; Lund-Katz, Sissel et al. (2017) Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A 114:968-973
Mayne, Leland (2016) Hydrogen Exchange Mass Spectrometry. Methods Enzymol 566:335-56
Hu, Wenbing; Kan, Zhong-Yuan; Mayne, Leland et al. (2016) Cytochrome c folds through foldon-dependent native-like intermediates in an ordered pathway. Proc Natl Acad Sci U S A 113:3809-14
Englander, S Walter; Mayne, Leland; Kan, Zhong-Yuan et al. (2016) Protein Folding-How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry. Annu Rev Biophys 45:135-52
Casina, Veronica C; Hu, Wenbing; Mao, Jian-Hua et al. (2015) High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome. Proc Natl Acad Sci U S A 112:9620-5
Englander, S Walter; Mayne, Leland (2014) The nature of protein folding pathways. Proc Natl Acad Sci U S A 111:15873-80
Hu, Wenbing; Walters, Benjamin T; Kan, Zhong-Yuan et al. (2013) Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A 110:7684-9

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