Mechanism of Cell Intoxication by Hybrid Toxins

Chang, Ta-Min

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 5R01GM033754-05
• Application #: 3283715
• Study Section: Experimental Therapeutics Subcommittee 1 (ET)
• Project Start: 1985-09-01
• Project End: 1992-07-31
• Budget Start: 1992-04-01
• Budget End: 1992-07-31
• Support Year: 5
• Fiscal Year: 1992

Institution

• Name: Genesee Hospital
• City: Rochester
• State: NY
• Country: United States
• Zip Code: 14607

Publications

Chang, T M; Hossain, A; Chang, C H (1994) Effect of rate of intracellular transport and diacytosis on cytotoxicity of hybrid toxins. Study with hybrids using hepatic asialoglycoprotein receptor-mediated endocytosis. Biochim Biophys Acta 1224:77-88

Chang, T M; Chang, C H (1989) Study on the variables affecting toxicity of hybrid toxins. The effect of different target cell receptor distribution and toxin binding chain. Biochim Biophys Acta 1013:239-46

Chang, T M; Chakraborti, P; Chang, C H (1989) The cyanogen bromide fragment I of asialoorosomucoid is transported more efficiently than asialoorosomucoid in rat hepatocytes. Biochim Biophys Acta 1010:166-76

Chang, T M; Chang, C H (1989) Diacytosis of asialoglycoprotein in isolated hepatocytes is dependent on the structure of ligand and cellular distribution of the receptors. Biochim Biophys Acta 1014:229-34

Chang, T M; Chang, C L (1988) Hepatic uptake of asialoglycoprotein is different among mammalian species due to different receptor distribution. Biochim Biophys Acta 942:57-64