Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034351-12
Application #
2177385
Study Section
Special Emphasis Panel (ZRG3-BMT (04))
Project Start
1984-12-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Holbrook, J A; Capp, M W; Saecker, R M et al. (1999) Enthalpy and heat capacity changes for formation of an oligomeric DNA duplex: interpretation in terms of coupled processes of formation and association of single-stranded helices. Biochemistry 38:8409-22
Zhang, W; Ni, H; Capp, M W et al. (1999) The importance of coulombic end effects: experimental characterization of the effects of oligonucleotide flanking charges on the strength and salt dependence of oligocation (L8+) binding to single-stranded DNA oligomers. Biophys J 76:1008-17
Record Jr, M T; Courtenay, E S; Cayley, S et al. (1998) Biophysical compensation mechanisms buffering E. coli protein-nucleic acid interactions against changing environments. Trends Biochem Sci 23:190-4
Record Jr, M T; Zhang, W; Anderson, C F (1998) Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: a practical guide to recognizing and interpreting polyelectrolyte effects, Hofmeister effects, and osmotic effects of salts. Adv Protein Chem 51:281-353
Padmanabhan, S; Zhang, W; Capp, M W et al. (1997) Binding of cationic (+4) alanine- and glycine-containing oligopeptides to double-stranded DNA: thermodynamic analysis of effects of coulombic interactions and alpha-helix induction. Biochemistry 36:5193-206
Zhang, W; Bond, J P; Anderson, C F et al. (1996) Large electrostatic differences in the binding thermodynamics of a cationic peptide to oligomeric and polymeric DNA. Proc Natl Acad Sci U S A 93:2511-6
Olmsted, M C; Bond, J P; Anderson, C F et al. (1995) Grand canonical Monte Carlo molecular and thermodynamic predictions of ion effects on binding of an oligocation (L8+) to the center of DNA oligomers. Biophys J 68:634-47
Record Jr, M T; Anderson, C F (1995) Interpretation of preferential interaction coefficients of nonelectrolytes and of electrolyte ions in terms of a two-domain model. Biophys J 68:786-94
Anderson, C F; Record Jr, M T (1995) Salt-nucleic acid interactions. Annu Rev Phys Chem 46:657-700
Bond, J P; Anderson, C F; Record Jr, M T (1994) Conformational transitions of duplex and triplex nucleic acid helices: thermodynamic analysis of effects of salt concentration on stability using preferential interaction coefficients. Biophys J 67:825-36

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