Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034767-11
Application #
2177564
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1985-07-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Liu, Jia; Segal, Mark R; Kelly, Mark J S et al. (2013) 13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation. Anesthesiology 119:1120-36
Liu, Jia; Litt, Lawrence; Segal, Mark R et al. (2011) Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites. Int J Mol Sci 12:6469-501
Liu, Jia; Litt, Lawrence; Segal, Mark R et al. (2011) Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia. J Cereb Blood Flow Metab 31:547-59
Liu, J; Segal, M; Yoo, S et al. (2009) Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress. Neurochem Int 54:106-10
Liu, Jia; Hirai, Kiyoshi; Litt, Lawrence (2008) Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices. Brain Res 1238:230-8
Zeng, Jianying; Yang, Guo-Yuan; Ying, Weihai et al. (2007) Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J Cereb Blood Flow Metab 27:304-15
Zeng, Jianying; Hirai, Kiyoshi; Yang, Guo-Yuan et al. (2004) Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices. J Bioenerg Biomembr 36:415-9
Hirai, K; Hayashi, T; Chan, P H et al. (2003) Akt phosphorylation and cell survival after hypoxia-induced cytochrome c release in superfused respiring neonatal rat cerebrocortical slices. Acta Neurochir Suppl 86:227-30
Litt, L; Hirai, K; Basus, V J et al. (2003) NTP and PCr responses to hypoxia by hypothermic and normothermic respiring, superfused, neonatal rat cerebrocortical slices: an NMR spectroscopy study at 14.1 Tesla. Acta Neurochir Suppl 86:71-4
Litt, Lawrence; Hirai, Kiyoshi; Basus, Vladimir J et al. (2003) Temperature control of respiring rat brain slices during high field NMR spectroscopy. Brain Res Brain Res Protoc 10:191-8

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