Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035141-10
Application #
2177759
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1985-07-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Surgery
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Austen Jr, W G; Kobzik, L; Carroll, M C et al. (2003) The role of complement and natural antibody in intestinal ischemia-reperfusion injury. Int J Immunopathol Pharmacol 16:1-8
Kyriakides, C; Austen Jr, W G; Wang, Y et al. (2001) Mast cells mediate complement activation after acid aspiration. Shock 16:21-4
Kyriakides, C; Favuzza, J; Wang, Y et al. (2001) Recombinant soluble P-selectin glycoprotein ligand 1 moderates local and remote injuries following experimental lower-torso ischaemia. Br J Surg 88:825-30
Kyriakides, C; Jasleen, J; Wang, Y et al. (2001) Neutrophils, not complement, mediate the mortality of experimental hemorrhagic pancreatitis. Pancreas 22:40-6
Kyriakides, C; Wang, Y; Austen Jr, W G et al. (2001) Moderation of skeletal muscle reperfusion injury by a sLe(x)-glycosylated complement inhibitory protein. Am J Physiol Cell Physiol 281:C224-30
Kyriakides, C; Wang, Y; Austen Jr, W G et al. (2001) Sialyl Lewis(x) hybridized complement receptor type 1 moderates acid aspiration injury. Am J Physiol Lung Cell Mol Physiol 281:L1494-9
Kyriakides, C; Woodcock, S A; Wang, Y et al. (2000) Soluble P-selectin moderates complement-dependent reperfusion injury of ischemic skeletal muscle. Am J Physiol Cell Physiol 279:C520-8
Woodcock, S A; Kyriakides, C; Wang, Y et al. (2000) Soluble P-selectin moderates complement dependent injury. Shock 14:610-5
Kyriakides, C; Austen Jr, W; Wang, Y et al. (2000) Endothelial selectin blockade attenuates lung permeability of experimental acid aspiration. Surgery 128:327-31
Kyriakides, C; Austen Jr, W G; Wang, Y et al. (2000) Neutrophil mediated remote organ injury after lower torso ischemia and reperfusion is selectin and complement dependent. J Trauma 48:32-8

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