Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036387-09
Application #
2178337
Study Section
Physiology Study Section (PHY)
Project Start
1986-12-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Physiology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Boyd-Tressler, Andrea M; Lane, Graham S; Dubyak, George R (2017) Up-regulated Ectonucleotidases in Fas-Associated Death Domain Protein- and Receptor-Interacting Protein Kinase 1-Deficient Jurkat Leukemia Cells Counteract Extracellular ATP/AMP Accumulation via Pannexin-1 Channels during Chemotherapeutic Drug-Induced Apo Mol Pharmacol 92:30-47
Portillo, Jose-Andres C; Lopez Corcino, Yalitza; Miao, Yanling et al. (2017) CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy. Diabetes 66:483-493
Karmakar, Mausita; Katsnelson, Michael A; Dubyak, George R et al. (2016) Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1? secretion in response to ATP. Nat Commun 7:10555
Katsnelson, Michael A; Lozada-Soto, Kristen M; Russo, Hana M et al. (2016) NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx. Am J Physiol Cell Physiol 311:C83-C100
Martin, Bradley N; Wang, Chenhui; Zhang, Cun-jin et al. (2016) T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol 17:583-92
Russo, Hana M; Rathkey, Joseph; Boyd-Tressler, Andrea et al. (2016) Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol 197:1353-67
Antonopoulos, Christina; Russo, Hana M; El Sanadi, Caroline et al. (2015) Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. J Biol Chem 290:20167-84
Karmakar, Mausita; Katsnelson, Michael; Malak, Hesham A et al. (2015) Neutrophil IL-1? processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol 194:1763-75
Lee, Karin L; Shukla, Sourabh; Wu, Mengzhi et al. (2015) Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X. Acta Biomater 19:166-79
Kiselar, Janna G; Wang, Xiaowei; Dubyak, George R et al. (2015) Modification of ?-Defensin-2 by Dicarbonyls Methylglyoxal and Glyoxal Inhibits Antibacterial and Chemotactic Function In Vitro. PLoS One 10:e0130533

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