Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036633-09
Application #
2178467
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1986-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Pharmacy
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Horng, Howard; Benet, Leslie Z (2013) The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Drug Metab Dispos 41:1923-33
Horng, Howard; Benet, Leslie Z (2013) Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chem Res Toxicol 26:465-76
Grillo, Mark P; Wait, Jill C M; Tadano Lohr, Michelle et al. (2010) Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Drug Metab Dispos 38:133-42
Grillo, Mark P; Hua, Fengmei; March, Kristi L et al. (2008) Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Chem Res Toxicol 21:1933-8
Li, Chunze; Grillo, Mark P; Badagnani, Ilaria et al. (2008) Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Drug Metab Dispos 36:682-7
Olsen, Jorgen; Li, Chunze; Skonberg, Christian et al. (2007) Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Drug Metab Dispos 35:758-64
Olsen, Jorgen; Li, Chunze; Bjornsdottir, Inga et al. (2005) In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chem Res Toxicol 18:1729-36
Wu, Chi-Yuan; Benet, Leslie Z (2005) Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 22:11-23
Chang, Jae H; Benet, Leslie Z (2005) Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Mol Pharm 2:428-34
Mohri, Kiminori; Okada, Kenji; Benet, Leslie Z (2005) Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes. Pharm Res 22:79-85

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