Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037639-10
Application #
2178856
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1989-09-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Storrs-Mansfield
State
CT
Country
United States
Zip Code
06269
Wowor, Andy J; Yan, Yuetian; Auclair, Sarah M et al. (2014) Analysis of SecA dimerization in solution. Biochemistry 53:3248-60
Bhanu, Meera K; Kendall, Debra A (2014) Fluorescence spectroscopy of soluble E. coli SPase I ?2-75 reveals conformational changes in response to ligand binding. Proteins 82:596-606
Bhanu, Meera K; Zhao, Ping; Kendall, Debra A (2013) Mapping of the SecA signal peptide binding site and dimeric interface by using the substituted cysteine accessibility method. J Bacteriol 195:4709-15
Yu, Dongmei; Wowor, Andy J; Cole, James L et al. (2013) Defining the Escherichia coli SecA dimer interface residues through in vivo site-specific photo-cross-linking. J Bacteriol 195:2817-25
De Bona, Paolo; Deshmukh, Lalit; Gorbatyuk, Vitaliy et al. (2012) Structural studies of a signal peptide in complex with signal peptidase I cytoplasmic domain: the stabilizing effect of membrane-mimetics on the acquired fold. Proteins 80:807-17
Wowor, Andy J; Yu, Dongmei; Kendall, Debra A et al. (2011) Energetics of SecA dimerization. J Mol Biol 408:87-98
Auclair, Sarah M; Moses, Julia P; Musial-Siwek, Monika et al. (2010) Mapping of the signal peptide-binding domain of Escherichia coli SecA using Förster resonance energy transfer. Biochemistry 49:782-92
Musial-Siwek, Monika; Yeagle, Philip L; Kendall, Debra A (2008) A small subset of signal peptidase residues are perturbed by signal peptide binding. Chem Biol Drug Des 72:140-6
Musial-Siwek, Monika; Kendall, Debra A; Yeagle, Philip L (2008) Solution NMR of signal peptidase, a membrane protein. Biochim Biophys Acta 1778:937-44
Rusch, Sharyn L; Kendall, Debra A (2007) Oligomeric states of the SecA and SecYEG core components of the bacterial Sec translocon. Biochim Biophys Acta 1768:5-12

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