Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM038608-09
Application #
2179426
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1990-09-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Marintchev, Assen; Edmonds, Katherine A; Marintcheva, Boriana et al. (2009) Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell 136:447-60
Roehrl, Michael H A; Wang, Julia Y; Wagner, Gerhard (2004) A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. Biochemistry 43:16056-66
Roehrl, Michael H A; Kang, Sunghyun; Aramburu, Jose et al. (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A 101:7554-9
Roehrl, Michael H A; Wang, Julia Y; Wagner, Gerhard (2004) Discovery of small-molecule inhibitors of the NFAT--calcineurin interaction by competitive high-throughput fluorescence polarization screening. Biochemistry 43:16067-75
Gross, John D; Gelev, Vladimir M; Wagner, Gerhard (2003) A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes. J Biomol NMR 25:235-42
Roehrl, Michael H A; Hyberts, Sven G; Sun, Zhen-Yu Jim et al. (2003) Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS. J Biomol NMR 26:373-4
Lugovskoy, Alexey A; Degterev, Alexei I; Fahmy, Amr F et al. (2002) A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc 124:1234-40
Muller, Jens; Lugovskoy, Alexey A; Wagner, Gerhard et al. (2002) NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase. Biochemistry 41:42-51
Zhou, P; Lugovskoy, A A; McCarty, J S et al. (2001) Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. Proc Natl Acad Sci U S A 98:6051-5
Krezel, A M; Ulmer, J S; Wagner, G et al. (2000) Recombinant decorsin: dynamics of the RGD recognition site. Protein Sci 9:1428-38

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