Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM039553-09
Application #
2179915
Study Section
Immunobiology Study Section (IMB)
Project Start
1988-02-01
Project End
1997-06-30
Budget Start
1996-02-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Xu, Zheng; Weiss, Arthur (2002) Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nat Immunol 3:764-71
Lynch, K W; Weiss, A (2001) A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer. J Biol Chem 276:24341-7
Sosinowski, T; Killeen, N; Weiss, A (2001) The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 15:457-66
Sosinowski, T; Pandey, A; Dixit, V M et al. (2000) Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med 191:463-74
Majeti, R; Xu, Z; Parslow, T G et al. (2000) An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 103:1059-70
Lynch, K W; Weiss, A (2000) A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol Cell Biol 20:70-80
van Oers, N S; Love, P E; Shores, E W et al. (1998) Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs. J Immunol 160:163-70
Page, S T; van Oers, N S; Perlmutter, R M et al. (1997) Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur J Immunol 27:554-62
Chu, D H; Spits, H; Peyron, J F et al. (1996) The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J 15:6251-61
van Oers, N S; Lowin-Kropf, B; Finlay, D et al. (1996) alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5:429-36

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