Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM041712-16
Application #
6690722
Study Section
Mammalian Genetics Study Section (MGN)
Program Officer
Wolfe, Paul B
Project Start
1989-12-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
16
Fiscal Year
2004
Total Cost
$303,200
Indirect Cost
Name
University of Washington
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Le, Quy; Maizels, Nancy (2015) Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID. PLoS Genet 11:e1005411
Maizels, Nancy (2013) Genome engineering with Cre-loxP. J Immunol 191:5-6
Humbert, Olivier; Davis, Luther; Maizels, Nancy (2012) Targeted gene therapies: tools, applications, optimization. Crit Rev Biochem Mol Biol 47:264-81
Yabuki, Munehisa; Cummings, W Jason; Leppard, John B et al. (2012) Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network. PLoS One 7:e36032
Sacho, Elizabeth J; Maizels, Nancy (2011) DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons. J Biol Chem 286:44945-51
Davis, Luther; Maizels, Nancy (2011) DNA nicks promote efficient and safe targeted gene correction. PLoS One 6:e23981
Eddy, Johanna; Vallur, Aarthy C; Varma, Sudir et al. (2011) G4 motifs correlate with promoter-proximal transcriptional pausing in human genes. Nucleic Acids Res 39:4975-83
Yabuki, Munehisa; Ordinario, Ellen C; Cummings, W Jason et al. (2009) E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol 182:408-15
Ordinario, Ellen C; Yabuki, Munehisa; Larson, Ryan P et al. (2009) Temporal regulation of Ig gene diversification revealed by single-cell imaging. J Immunol 183:4545-53
Ordinario, Ellen C; Yabuki, Munehisa; Handa, Priya et al. (2009) RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regions. BMC Mol Biol 10:98

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