Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM045335-06
Application #
2183091
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1991-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Erales, Jenny; Coffino, Philip (2014) Ubiquitin-independent proteasomal degradation. Biochim Biophys Acta 1843:216-21
Too, Priscilla Hiu-Mei; Erales, Jenny; Simen, Joana Danica et al. (2013) Slippery substrates impair function of a bacterial protease ATPase by unbalancing translocation versus exit. J Biol Chem 288:13243-57
Park, Soyeon; Li, Xueming; Kim, Ho Min et al. (2013) Reconfiguration of the proteasome during chaperone-mediated assembly. Nature 497:512-6
Erales, Jenny; Hoyt, Martin A; Troll, Fabian et al. (2012) Functional asymmetries of proteasome translocase pore. J Biol Chem 287:18535-43
Henderson, Allen; Erales, Jenny; Hoyt, Martin A et al. (2011) Dependence of proteasome processing rate on substrate unfolding. J Biol Chem 286:17495-502
Hoyt, Martin A; Zhang, Mingsheng; Coffino, Philip (2005) Probing the ubiquitin/proteasome system with ornithine decarboxylase, a ubiquitin-independent substrate. Methods Enzymol 398:399-413
Verma, Rati; Peters, Noel R; D'Onofrio, Mariapina et al. (2004) Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science 306:117-20
Zhang, Mingsheng; MacDonald, Alasdair I; Hoyt, Martin A et al. (2004) Proteasomes begin ornithine decarboxylase digestion at the C terminus. J Biol Chem 279:20959-65
Zhang, Mingsheng; Coffino, Philip (2004) Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome substrate processing. J Biol Chem 279:8635-41
Zhang, Mingsheng; Pickart, Cecile M; Coffino, Philip (2003) Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J 22:1488-96

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