Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM047856-06
Application #
6363254
Study Section
Special Emphasis Panel (ZRG1-MDCN-3 (01))
Program Officer
Shapiro, Bert I
Project Start
1994-05-01
Project End
2004-02-29
Budget Start
2001-03-01
Budget End
2002-02-28
Support Year
6
Fiscal Year
2001
Total Cost
$270,503
Indirect Cost
Name
University of Wisconsin Madison
Department
Biochemistry
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Loukin, Stephen; Su, Zhenwei; Kung, Ching (2011) Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations. PLoS One 6:e19533
Loukin, Stephen; Zhou, Xinliang; Su, Zhenwei et al. (2010) Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force. J Biol Chem 285:27176-81
Kung, Ching; Martinac, Boris; Sukharev, Sergei (2010) Mechanosensitive channels in microbes. Annu Rev Microbiol 64:313-29
Su, Zhenwei; Zhou, Xinliang; Loukin, Stephen H et al. (2009) Mechanical force and cytoplasmic Ca(2+) activate yeast TRPY1 in parallel. J Membr Biol 227:141-50
Loukin, Stephen H; Su, Zhenwei; Kung, Ching (2009) Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids. FEBS Lett 583:754-8
Martinac, Boris; Saimi, Yoshiro; Kung, Ching (2008) Ion channels in microbes. Physiol Rev 88:1449-90
Myers, Benjamin R; Saimi, Yoshiro; Julius, David et al. (2008) Multiple unbiased prospective screens identify TRP channels and their conserved gating elements. J Gen Physiol 132:481-6
Loukin, Stephen; Zhou, Xinliang; Kung, Ching et al. (2008) A genome-wide survey suggests an osmoprotective role for vacuolar Ca2+ release in cell wall-compromised yeast. FASEB J 22:2405-15
John Haynes, W; Zhou, Xin-Liang; Su, Zhen-Wei et al. (2008) Indole and other aromatic compounds activate the yeast TRPY1 channel. FEBS Lett 582:1514-8
Su, Zhenwei; Zhou, Xinliang; Haynes, W John et al. (2007) Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channels. Proc Natl Acad Sci U S A 104:19607-12

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