Pyruvate Decarboxylase Structure-Function Relationships

Furey, William F.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 2R01GM048195-05
• Application #: 2185680
• Study Section: Special Emphasis Panel (ZRG3-BBCA (01))
• Project Start: 1992-08-01
• Project End: 2000-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: University of Pittsburgh
• Department: Miscellaneous
• Type: Schools of Arts and Sciences
• DUNS #: 053785812
• City: Pittsburgh
• State: PA
• Country: United States
• Zip Code: 15213

Publications

Zeng, X; Farrenkopf, B; Hohmann, S et al. (1993) Role of cysteines in the activation and inactivation of brewers' yeast pyruvate decarboxylase investigated with a PDC1-PDC6 fusion protein. Biochemistry 32:2704-9

Muller, Y A; Lindqvist, Y; Furey, W et al. (1993) A thiamin diphosphate binding fold revealed by comparison of the crystal structures of transketolase, pyruvate oxidase and pyruvate decarboxylase. Structure 1:95-103

Dyda, F; Furey, W; Swaminathan, S et al. (1993) Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution. Biochemistry 32:6165-70