Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049370-05
Application #
2186967
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1992-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Hyun, Joogyung; Hashimoto, Carl (2011) Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila. Fly (Austin) 5:53-7
Tang, Huaping (2009) Regulation and function of the melanization reaction in Drosophila. Fly (Austin) 3:105-11
Scherfer, Christoph; Tang, Huaping; Kambris, Zakaria et al. (2008) Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Dev Biol 323:189-96
Tang, Huaping; Kambris, Zakaria; Lemaitre, Bruno et al. (2008) A serpin that regulates immune melanization in the respiratory system of Drosophila. Dev Cell 15:617-26
Jang, In-Hwan; Chosa, Naoyuki; Kim, Sung-Hee et al. (2006) A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Dev Cell 10:45-55
Tang, Huaping; Kambris, Zakaria; Lemaitre, Bruno et al. (2006) Two proteases defining a melanization cascade in the immune system of Drosophila. J Biol Chem 281:28097-104
Richer, Martin J; Juliano, Luiz; Hashimoto, Carl et al. (2004) Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity. J Biol Chem 279:10222-7
Richer, Martin J; Keays, Clairessa A; Waterhouse, Jennifer et al. (2004) The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Proc Natl Acad Sci U S A 101:10560-5
Hashimoto, Carl; Kim, Dong Ryoung; Weiss, Linnea A et al. (2003) Spatial regulation of developmental signaling by a serpin. Dev Cell 5:945-50
Turcotte, Cynthia L; Hashimoto, Carl (2002) Evidence for a glycosaminoglycan on the nudel protein important for dorsoventral patterning of the drosophila embryo. Dev Dyn 224:51-7

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