Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051650-16
Application #
2190326
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1980-07-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1997-12-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Keniry, M A; Owen, E A; Shafer, R H (2000) The three-dimensional structure of the 4:1 mithramycin:d(ACCCGGGT)(2) complex: evidence for an interaction between the E saccharides. Biopolymers 54:104-14
Keniry, M A (2000) Quadruplex structures in nucleic acids. Biopolymers 56:123-46
Strahan, G D; Keniry, M A; Shafer, R H (1998) NMR structure refinement and dynamics of the K+-[d(G3T4G3)]2 quadruplex via particle mesh Ewald molecular dynamics simulations. Biophys J 75:968-81
Shafer, R H (1998) Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands. Prog Nucleic Acid Res Mol Biol 59:55-94
He, Y; Scaria, P V; Shafer, R H (1997) Studies on formation and stability of the d[G(AG)5]* d[G(AG)5]. d[C(TC)5] and d[G(TG)5]* d[G(AG)5]. d[C(TC)5] triple helices. Biopolymers 41:431-41
Keniry, M A; Owen, E A; Shafer, R H (1997) The contribution of thymine-thymine interactions to the stability of folded dimeric quadruplexes. Nucleic Acids Res 25:4389-92
Chen, Q; Shafer, R H; Kuntz, I D (1997) Structure-based discovery of ligands targeted to the RNA double helix. Biochemistry 36:11402-7
Chen, Q; Kuntz, I D; Shafer, R H (1996) Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye. Proc Natl Acad Sci U S A 93:2635-9
Nikolaev, V A; Grokhovsky, S L; Surovaya, A N et al. (1996) Design of sequence-specific DNA binding ligands that use a two-stranded peptide motif for DNA sequence recognition. J Biomol Struct Dyn 14:31-47
Keniry, M A; Strahan, G D; Owen, E A et al. (1995) Solution structure of the Na+ form of the dimeric guanine quadruplex [d(G3T4G3)]2. Eur J Biochem 233:631-43

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