The purpose of this work is to characterize the genetic changes that occur during speciation. One of our goals is to analyze the genetics of postzygotic isolation in Drosophila;we will focus on the role of meiotic drive in the evolution of postzygotic isolation. We also propose to turn to the study of prezygotic (behavioral) isolation in Drosophila;our goal is to identify and characterize the actual genes that cause behavioral isolation between species. Using genetic and molecular population genetic approaches, we will address the following questions: 1) Does meiotic drive cause the evolution of hybrid sterility? 2) What is the identity of the genes that cause hybrid sterility and hybrid meiotic drive? 3) What is the identity of the genes that cause behavioral isolation between species? 4) Do these genes, like the ones that cause postzygotic isolation, evolve rapidly between species? 5) If so, is this rapid evolution driven by positive natural selection? We will attempt to answer these questions by analysis of D. pseudoobscura Bogota-USA and D. sechellia-D. mauritiana hybrids. Our long-term goal is to understand how animal species, including humans, arise by determining the genetic causes of speciation.

Public Health Relevance

Our goal is to understand how animal species, including humans, arise by discovering the genetic causes of speciation. This goal is relevant to NIH's mission as recent studies have shown that analysis of species hybrids provides a surprising route to discovery of functionally important genes that- despite their significance- change rapidly between populations or species.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051932-17
Application #
8245201
Study Section
Genetic Variation and Evolution Study Section (GVE)
Program Officer
Eckstrand, Irene A
Project Start
1995-05-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
17
Fiscal Year
2012
Total Cost
$289,602
Indirect Cost
$102,157
Name
University of Rochester
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Ahmed-Braimah, Yasir H (2016) Multiple Genes Cause Postmating Prezygotic Reproductive Isolation in the Drosophila virilis Group. G3 (Bethesda) 6:4067-4076
Alfonso-Parra, Catalina; Ahmed-Braimah, Yasir H; Degner, Ethan C et al. (2016) Mating-Induced Transcriptome Changes in the Reproductive Tract of Female Aedes aegypti. PLoS Negl Trop Dis 10:e0004451
Ahmed-Braimah, Yasir H; Sweigart, Andrea L (2015) A single gene causes an interspecific difference in pigmentation in Drosophila. Genetics 200:331-42
McNabney, Daniel R (2012) The genetic basis of behavioral isolation between Drosophila mauritiana and D. sechellia. Evolution 66:2182-90
Phadnis, Nitin (2011) Genetic architecture of male sterility and segregation distortion in Drosophila pseudoobscura Bogota-USA hybrids. Genetics 189:1001-9
Sweigart, Andrea L (2010) Simple Y-autosomal incompatibilities cause hybrid male sterility in reciprocal crosses between Drosophila virilis and D. americana. Genetics 184:779-87
Orr, H Allen (2010) The population genetics of beneficial mutations. Philos Trans R Soc Lond B Biol Sci 365:1195-201
Sweigart, Andrea L (2010) The genetics of postmating, prezygotic reproductive isolation between Drosophila virilis and D. americana. Genetics 184:401-10
Orr, H Allen (2009) Fitness and its role in evolutionary genetics. Nat Rev Genet 10:531-9
Unckless, R L; Orr, H A (2009) Dobzhansky-Muller incompatibilities and adaptation to a shared environment. Heredity 102:214-7

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