Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053457-01A1
Application #
2192820
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Kim, Soo Jung; Yoon, Jae Seok; Shishido, Hideki et al. (2015) Protein folding. Translational tuning optimizes nascent protein folding in cells. Science 348:444-8
Conti, Brian J; Devaraneni, Prasanna K; Yang, Zhongying et al. (2015) Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. Mol Cell 58:269-83
Patterson, Melissa A; Bandyopadhyay, Anannya; Devaraneni, Prasanna K et al. (2015) The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding. J Biol Chem 290:28944-52
Conti, Brian J; Elferich, Johannes; Yang, Zhongying et al. (2014) Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex. Nat Struct Mol Biol 21:228-35
Matsumura, Yoshihiro; Sakai, Juro; Skach, William R (2013) Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase. J Biol Chem 288:31069-79
Kelkar, Devaki A; Khushoo, Amardeep; Yang, Zhongying et al. (2012) Kinetic analysis of ribosome-bound fluorescent proteins reveals an early, stable, cotranslational folding intermediate. J Biol Chem 287:2568-78
Devaraneni, Prasanna K; Conti, Brian; Matsumura, Yoshihiro et al. (2011) Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex. Cell 146:134-47
Khushoo, Amardeep; Yang, Zhongying; Johnson, Arthur E et al. (2011) Ligand-driven vectorial folding of ribosome-bound human CFTR NBD1. Mol Cell 41:682-92
Matsumura, Yoshihiro; David, Larry L; Skach, William R (2011) Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell 22:2797-809
Peters, Kathryn W; Okiyoneda, Tsukasa; Balch, William E et al. (2011) CFTR Folding Consortium: methods available for studies of CFTR folding and correction. Methods Mol Biol 742:335-53

Showing the most recent 10 out of 21 publications