Chaperones and membrane protein biogenesis

Cyr, Douglas M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 5R01GM056981-08
• Application #: 6691086
• Study Section: Medical Biochemistry Study Section (MEDB)
• Program Officer: Wehrle, Janna P
• Project Start: 1998-01-01
• Project End: 2006-12-31
• Budget Start: 2004-01-01
• Budget End: 2004-12-31
• Support Year: 8
• Fiscal Year: 2004
• Total Cost: $292,909

Institution

• Name: University of North Carolina Chapel Hill
• Department: Anatomy/Cell Biology
• Type: Schools of Medicine
• DUNS #: 608195277
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Sopha, Pattarawut; Ren, Hong Yu; Grove, Diane E et al. (2017) Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis. J Biol Chem 292:11792-11803

Cheng, Zhaokang; Zhu, Qiang; Dee, Rachel et al. (2017) Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J Biol Chem 292:2065-2079

Gentzsch, Martina; Ren, Hong Y; Houck, Scott A et al. (2016) Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770. Am J Physiol Lung Cell Mol Physiol 311:L550-9

Veit, Gudio; Avramescu, Radu G; Chiang, Annette N et al. (2016) From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. Mol Biol Cell 27:424-33

Vermulst, Marc; Denney, Ashley S; Lang, Michael J et al. (2015) Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun 6:8065

Cyr, Douglas M; Ramos, Carlos H (2015) Specification of Hsp70 function by Type I and Type II Hsp40. Subcell Biochem 78:91-102

Wolfe, Katie J; Ren, Hong Yu; Trepte, Philipp et al. (2014) Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins. PLoS One 9:e95914

Houck, Scott A; Ren, Hong Yu; Madden, Victoria J et al. (2014) Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR. Mol Cell 54:166-179

Suzuki, Shingo; Shuto, Tsuyoshi; Sato, Takashi et al. (2014) Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter. Sci Rep 4:4258

Ren, Hong Yu; Grove, Diane E; De La Rosa, Oxana et al. (2013) VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1. Mol Biol Cell 24:3016-24