Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM059118-01
Application #
2824649
Study Section
Molecular Biology Study Section (MBY)
Project Start
1999-05-01
Project End
2000-07-31
Budget Start
1999-05-01
Budget End
2000-07-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Massachusetts Amherst
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
153223151
City
Amherst
State
MA
Country
United States
Zip Code
01003
Ong, Poh Chee; McGowan, Sheena; Pearce, Mary C et al. (2007) DNA accelerates the inhibition of human cathepsin V by serpins. J Biol Chem 282:36980-6
Popova, Evgenya Y; Claxton, David F; Lukasova, Emilie et al. (2006) Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood. Exp Hematol 34:453-62
McGowan, Sheena; Buckle, Ashley M; Irving, James A et al. (2006) X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. EMBO J 25:3144-55
Grigoryev, Sergei A; Nikitina, Tatiana; Pehrson, John R et al. (2004) Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence. J Cell Sci 117:6153-62
Grigoryev, Sergei A (2004) Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays. FEBS Lett 564:4-8
Istomina, Natalia E; Shushanov, Sain S; Springhetti, Evelyn M et al. (2003) Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT. Mol Cell Biol 23:6455-68
Springhetti, Evelyn M; Istomina, Natalia E; Whisstock, James C et al. (2003) Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT. J Biol Chem 278:43384-93
Irving, James A; Shushanov, Sain S; Pike, Robert N et al. (2002) Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem 277:13192-201
Grigoryev, S A (2001) Higher-order folding of heterochromatin: protein bridges span the nucleosome arrays. Biochem Cell Biol 79:227-41