In sum, overall the project suffered an estimated 3 month set-back. We have requested supplementary funding for 3 months (25% of the current years direct cost award of $192,456 or $48,144) to cover this set-back. The primary request is to recoup salary associated with lost time (postdocs and PI salary) and a small amount to offset the cost of reagents and lab supplies required to recover experiments that were on-going at the time of the storm and to replace reagents for future use. Please see budget justification for additional details.

Public Health Relevance

Germ cells are the link from generation to generation and must proliferate to ensure fertility; and germ cell proliferation is controlled by interaction with neighboring cells and by hormones and nutrition. We study conserved molecular pathways that control germ cell proliferation. These investigations inform similar processes in humans with implications for fertility; cancer; and stem cell biology.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM061706-13S1
Application #
8666507
Study Section
Program Officer
Gaillard, Shawn R
Project Start
2014-01-01
Project End
2015-12-31
Budget Start
2014-01-01
Budget End
2015-12-31
Support Year
13
Fiscal Year
2014
Total Cost
$40,802
Indirect Cost
$16,730
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Hubbard, E Jane Albert (2014) FLP/FRT and Cre/lox recombination technology in C. elegans. Methods 68:417-24
Hubbard, E Jane Albert; Korta, Dorota Z; Dalfó, Diana (2013) Physiological control of germline development. Adv Exp Med Biol 757:101-31
Setty, Yaki; Dalfó, Diana; Korta, Dorota Z et al. (2012) A model of stem cell population dynamics: in silico analysis and in vivo validation. Development 139:47-56
Dalfó, Diana; Michaelson, David; Hubbard, E Jane Albert (2012) Sensory regulation of the C. elegans germline through TGF-?-dependent signaling in the niche. Curr Biol 22:712-9
Korta, Dorota Z; Tuck, Simon; Hubbard, E Jane Albert (2012) S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development 139:859-70
Hubbard, E Jane Albert (2011) Insulin and germline proliferation in Caenorhabditis elegans. Vitam Horm 87:61-77
Michaelson, David; Korta, Dorota Z; Capua, Yossi et al. (2010) Insulin signaling promotes germline proliferation in C. elegans. Development 137:671-80
Korta, Dorota Z; Hubbard, E Jane Albert (2010) Soma-germline interactions that influence germline proliferation in Caenorhabditis elegans. Dev Dyn 239:1449-59
Voutev, Roumen; Keating, Ryan; Hubbard, E Jane Albert et al. (2009) Characterization of the Caenorhabditis elegans Islet LIM-homeodomain ortholog, lim-7. FEBS Lett 583:456-64
McGovern, Marie; Voutev, Roumen; Maciejowski, John et al. (2009) A "latent niche" mechanism for tumor initiation. Proc Natl Acad Sci U S A 106:11617-22

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