In sum, overall the project suffered an estimated 3 month set-back. We have requested supplementary funding for 3 months (25% of the current years direct cost award of $192,456 or $48,144) to cover this set-back. The primary request is to recoup salary associated with lost time (postdocs and PI salary) and a small amount to offset the cost of reagents and lab supplies required to recover experiments that were on-going at the time of the storm and to replace reagents for future use. Please see budget justification for additional details.
Germ cells are the link from generation to generation and must proliferate to ensure fertility; and germ cell proliferation is controlled by interaction with neighboring cells and by hormones and nutrition. We study conserved molecular pathways that control germ cell proliferation. These investigations inform similar processes in humans with implications for fertility; cancer; and stem cell biology.
|Roy, Debasmita; Michaelson, David; Hochman, Tsivia et al. (2016) Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially. Dev Biol 409:261-71|
|Qin, Zhao; Hubbard, E Jane Albert (2015) Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells. Nat Commun 6:7107|
|Atwell, Kathryn; Qin, Zhao; Gavaghan, David et al. (2015) Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle. Development 142:3902-11|
|Deng, Xinzhu; Michaelson, David; Tchieu, Jason et al. (2015) Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors. PLoS One 10:e0127862|
|Hubbard, E Jane Albert (2014) FLP/FRT and Cre/lox recombination technology in C. elegans. Methods 68:417-24|
|Hubbard, E Jane Albert; Korta, Dorota Z; DalfÃ³, Diana (2013) Physiological control of germline development. Adv Exp Med Biol 757:101-31|
|Korta, Dorota Z; Tuck, Simon; Hubbard, E Jane Albert (2012) S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development 139:859-70|
|DalfÃ³, Diana; Michaelson, David; Hubbard, E Jane Albert (2012) Sensory regulation of the C. elegans germline through TGF-Î²-dependent signaling in the niche. Curr Biol 22:712-9|
|Setty, Yaki; DalfÃ³, Diana; Korta, Dorota Z et al. (2012) A model of stem cell population dynamics: in silico analysis and in vivo validation. Development 139:47-56|
|Hubbard, E Jane Albert (2011) Insulin and germline proliferation in Caenorhabditis elegans. Vitam Horm 87:61-77|
Showing the most recent 10 out of 25 publications