Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM066153-20
Application #
6687823
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Schwab, John M
Project Start
1998-03-20
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
20
Fiscal Year
2004
Total Cost
$262,147
Indirect Cost

  Institution

Name
Emory University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Varela-Alvarez, Adrian; Liebeskind, Lanny S; Musaev, Djamaladdin G (2012) Mechanistic Insights into the Aerobic Cu(I)-Catalyzed Cross-Coupling of S-Acyl Thiosalicylamide Thiol Esters and Boronic Acids. Organometallics 31:7958-7968
Li, Hao; He, Anyu; Falck, John R et al. (2011) Stereocontrolled synthesis of ?-amino-?'-alkoxy ketones by a copper-catalyzed cross-coupling of peptidic thiol esters and ?-alkoxyalkylstannanes. Org Lett 13:3682-5
Zhang, Zhihui; Lindale, Matthew G; Liebeskind, Lanny S (2011) Mobilizing Cu(I) for carbon-carbon bond forming catalysis in the presence of thiolate. Chemical mimicking of metallothioneins. J Am Chem Soc 133:6403-10
Wu, Wenting; Zhang, Zhihui; Liebeskind, Lanny S (2011) In situ carboxyl activation using a silatropic switch: a new approach to amide and peptide constructions. J Am Chem Soc 133:14256-9
Musaev, Djamaladdin G; Liebeskind, Lanny S (2009) On the Mechanism of Pd(0)-Catalyzed, Cu(I) Carboxylate-Mediated Thioorganic-Boronic Acid Desulfitative Coupling. A Non-innocent Role for Carboxylate Ligand. Organometallics 28:4639-4642
Zitomer, Nicholas C; Mitchell, Trevor; Voss, Kenneth A et al. (2009) Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. J Biol Chem 284:4786-95
Liebeskind, Lanny S; Yang, Hao; Li, Hao (2009) A copper-catalyzed, pH-neutral construction of high-enantiopurity peptidyl ketones from peptidic s-acylthiosalicylamides in air at room temperature. Angew Chem Int Ed Engl 48:1417-21
Li, Hao; Yang, Hao; Liebeskind, Lanny S (2008) Synthesis of high enantiopurity N-protected alpha-amino ketones by thiol ester-organostannane cross-coupling using pH-neutral conditions. Org Lett 10:4375-8
Liu, Songbai; Liebeskind, Lanny S (2008) A simple, modular synthesis of substituted pyridines. J Am Chem Soc 130:6918-9
Zhang, Zhihui; Yu, Ying; Liebeskind, Lanny S (2008) N-amidation by copper-mediated cross-coupling of organostannanes or boronic acids with o-acetyl hydroxamic acids. Org Lett 10:3005-8

Showing the most recent 10 out of 20 publications