Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM067260-06
Application #
6691730
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Basavappa, Ravi
Project Start
1998-12-15
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
6
Fiscal Year
2004
Total Cost
$287,470
Indirect Cost
Name
Boston University
Department
Physiology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Wilson, Christopher J; Das, Madhurima; Jayaraman, Shobini et al. (2018) Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry 57:4583-4596
Klimtchuk, Elena S; Prokaeva, Tatiana; Frame, Nicholas M et al. (2018) Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A 115:E6428-E6436
Jayaraman, Shobini; Gantz, Donald L; Haupt, Christian et al. (2018) Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner. Chem Commun (Camb) 54:3532-3535
Jayaraman, Shobini; Sánchez-Quesada, Jose Luis; Gursky, Olga (2017) Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases. Biochim Biophys Acta Mol Basis Dis 1863:200-210
Jayaraman, Shobini; Gantz, Donald L; Haupt, Christian et al. (2017) Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis. Proc Natl Acad Sci U S A 114:E6507-E6515
Frame, Nicholas M; Jayaraman, Shobini; Gantz, Donald L et al. (2017) Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a ""molecular mop"" in immune response. J Struct Biol 200:293-302
Madico, Guillermo; Gursky, Olga; Fairman, Jeff et al. (2017) Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens. Vaccines (Basel) 6:
Prokaeva, Tatiana; Akar, Harun; Spencer, Brian et al. (2017) Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant. Kidney Int Rep 2:1223-1232
Klimtchuk, Elena S; Prokaeva, Tatiana B; Spencer, Brian H et al. (2017) In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis. Amyloid 24:115-122
Frame, Nicholas M; Gursky, Olga (2017) Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. Amyloid 24:13-14

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