A supplement to R01 GM 75091 """"""""Theoretical Population Genetics"""""""" is sought. This will allow the addition of the involvement of Dr. Sharon R. Browning of the University of Auckland, New Zealand. Dr Browning will extend the multi-locus work of this project to association mapping for human disease genes, using the technique of whole-genome association. This addresses a timely and practical need and it extends the theoretical development in the original project by drawing on the expertise of Sharon Browning in markov chain and other probabilistic modelling tools as well as computational strategies. The proposed work will be based on Sharon Browning's recent sue of variable length Markov chains to define localized haplotype structures. It therefore automatically adjusts to linkage disequilibrium structure and avoids ad-hoc windowing strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM075091-02S1
Application #
7264081
Study Section
Genetic Variation and Evolution Study Section (GVE)
Program Officer
Anderson, Richard A
Project Start
2006-05-01
Project End
2010-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
2
Fiscal Year
2007
Total Cost
$94,979
Indirect Cost
Name
University of Washington
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Xue, Angli; Wu, Yang; Zhu, Zhihong et al. (2018) Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nat Commun 9:2941
Graffelman, Jan; Weir, Bruce S (2018) Multi-allelic exact tests for Hardy-Weinberg equilibrium that account for gender. Mol Ecol Resour 18:461-473
Goudet, Jérôme; Kay, Tomas; Weir, Bruce S (2018) How to estimate kinship. Mol Ecol 27:4121-4135
Qi, Ting; Wu, Yang; Zeng, Jian et al. (2018) Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nat Commun 9:2282
Graffelman, Jan; Weir, Bruce S (2018) On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers. Genet Epidemiol 42:34-48
Yengo, Loic; Zhu, Zhihong; Wray, Naomi R et al. (2018) Reply to Kardos et al.: Estimation of inbreeding depression from SNP data. Proc Natl Acad Sci U S A 115:E2494-E2495
Zheng, Xiuwen; Gogarten, Stephanie M; Lawrence, Michael et al. (2017) SeqArray-a storage-efficient high-performance data format for WGS variant calls. Bioinformatics 33:2251-2257
Galván-Femenía, Iván; Graffelman, Jan; Barceló-I-Vidal, Carles (2017) Graphics for relatedness research. Mol Ecol Resour 17:1271-1282
Puig, X; Ginebra, J; Graffelman, J (2017) A Bayesian test for Hardy-Weinberg equilibrium of biallelic X-chromosomal markers. Heredity (Edinb) 119:226-236
Graffelman, Jan; Jain, Deepti; Weir, Bruce (2017) A genome-wide study of Hardy-Weinberg equilibrium with next generation sequence data. Hum Genet 136:727-741

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