Studying the synthesis of natural products provides rich opportunities for identifying new directions in chemistry and biology. The overarching goal of our research program is to study the chemical synthesis of small-molecules of medicinal relevance and to advance chemical technology for the next-generation of drug synthesis. Through this project, we will better understand how nature performs cycloaddition-type dimerization reactions to produce higher order pyrrole-imidazole alkaloids. We will test the biosynthetic hypotheses and develop biomimetic synthetic approaches to these natural products. Inspired by the oxidative metalloenzymes, we will further develop new metal catalysts for C-H and olefin oxidation. Our research will have direct impacts on the discovery and manufacturing of small-molecule drugs.
This research project is directed toward advancing technologies for drug synthesis. We will develop new chemical methods to enable the efficient synthesis of natural products of medicinal relevance. The potential of these natural products as new anticancer drugs will be further evaluated in future studies.
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