Superstorm Sandy hit New York City on October 29, 2012. The resulting storm surge led to the closure of the Medical Science Building (MSB) at the NYU School of Medicine (SoM), in which my laboratory was located. The damage to MSB had a major impact on our research work performed in the months prior to the storm, as well as on laboratory operations during the subsequent months, with all of this work funded by R01 GM083185 (including an NIGMS Supplement for Collaborative Science). Because of this significant disruption of a full year of NIH funded activities, we request a one-year cost extension using funding opportunity RFA-OD-13-199.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM083185-04S1
Application #
8668405
Study Section
Program Officer
Anderson, Vernon
Project Start
2014-01-01
Project End
2015-12-31
Budget Start
2014-01-01
Budget End
2015-12-31
Support Year
4
Fiscal Year
2014
Total Cost
$204,176
Indirect Cost
$83,718
Name
New York University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Murphy, Anar K; Fitzgerald, Michael; Ro, Teresa et al. (2014) Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery. J Cell Biol 206:493-507
Bhatt, Purvi; d'Avout, Claire; Kane, Naomi S et al. (2012) Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination. FEBS J 279:370-83
Borowiec, James A; Schildkraut, Carl L (2011) Open sesame: activating dormant replication origins in the mouse immunoglobulin heavy chain (Igh) locus. Curr Opin Cell Biol 23:284-92
Brocardo, Mariana G; Borowiec, James A; Henderson, Beric R (2011) Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. Int J Biochem Cell Biol 43:1354-64
Lee, Dong-Hyun; Pan, Yunfeng; Kanner, Shlomo et al. (2010) A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat Struct Mol Biol 17:365-72
Vassin, Vitaly M; Anantha, Rachel William; Sokolova, Elena et al. (2009) Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress. J Cell Sci 122:4070-80
Anantha, Rachel William; Borowiec, James A (2009) Mitotic crisis: the unmasking of a novel role for RPA. Cell Cycle 8:357-61