There is a significant medical need for an adhesive that can bond strongly to soft tissues and incisions that facilitates healing and minimizes inflammation. These materials can potentially reduce operating time, tissue handling, and mitigate complications such as infection. While numerous tissue adhesives exist, their applications are restricted due to limitations such as insufficient mechanical properties, increased inflammation and difficulty in application to certain wound geometries. We have recently developed a textured tissue tape that is biocompatible with tunable mechanical, degradation and adhesive properties. Functional testing against tissue showed maximum adhesion strength of 0.8 N/cm2, but in order to translate these materials to medical applications, adhesion strengths of ~5-15 N/cm2 are required. In this proposal, we aim to develop an adhesive that bonds strongly and can be applied to a variety of tissues. We will reveal the fundamental scientific and engineering principles required to fabricate biologically interfacing adhesives with well-defined surface morphologies and chemistries without inducing a significant inflammatory response. Through enhancing the adhesion of our existing nanostructured tapes and through elucidating mechanisms that impact adhesion to different tissues, the proposed research will provide a potential platform for discovery of new science that leads to many practical and useful additions to the surgical armentarium. Specifically, a new class of strongly adhesive micro/nano textured biomaterials will be developed by controlling the surface features of biocompatible polymers on the micro and nanoscale, and by systematically developing an understanding of how topography, porosity, and chemistry influence adhesion to biological tissues. Through using soft, flexible materials, the textured surfaces should easily conform to irregularly shaped surfaces, such as soft tissue, thereby maximizing molecular interactions at the interface.
The aim of this proposal is to develop a novel tissue tape (i.e. an internal bandage) through engineered substrate topography and chemistry that can satisfy the current medical demand for an adhesive that can bond strongly to tissue and facilitate the wound healing process. The development of this novel biomedical material will have broad implications for wound repair of many tissues including gut, bladder, lung, dura, and muscle. Potential benefits include reduction in operating time, tissue handling, and mitigation of surgical complications such as infection by eliminating the need for sutures.
|Lang, Nora; Pereira, Maria J; Lee, Yuhan et al. (2014) A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects. Sci Transl Med 6:218ra6|
|Pereira, Maria J N; Sundback, Cathryn A; Lang, Nora et al. (2014) Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation. Adv Healthc Mater 3:565-71|
|Yang, Seung Yun; O'Cearbhaill, Eoin D; Sisk, Geoffroy C et al. (2013) A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue. Nat Commun 4:1702|
|Pereira, Maria Jose Nunes; Ouyang, Ben; Sundback, Cathryn A et al. (2013) A highly tunable biocompatible and multifunctional biodegradable elastomer. Adv Mater 25:1209-15|
|Mitsouras, Dimitris; Vemula, Praveen Kumar; Yu, Peng et al. (2011) Immobilized contrast-enhanced MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall. Magn Reson Med 65:176-83|
|Chan, Edwin P; Karp, Jeffrey M; Langer, Robert S (2011) A "Self-Pinning" Adhesive Based on Responsive Surface Wrinkles. J Polym Sci B Polym Phys 49:40-44|
|Ankrum, James; Karp, Jeffrey M (2010) Mesenchymal stem cell therapy: Two steps forward, one step back. Trends Mol Med 16:203-9|
|Kang, Sung Min; You, Inseong; Cho, Woo Kyung et al. (2010) One-step modification of superhydrophobic surfaces by a mussel-inspired polymer coating. Angew Chem Int Ed Engl 49:9401-4|
|Sarkar, Debanjan; Vemula, Praveen K; Zhao, Weian et al. (2010) Engineered mesenchymal stem cells with self-assembled vesicles for systemic cell targeting. Biomaterials 31:5266-74|