Two distinct approaches are being used to study complex cellular systems. The first approach automatically searches large datasets for correlations between genes and proteins and represents these as a graph with nodes and edges. The second approach painstakingly crafts detailed models that can be simulated by computer. These approaches have largely been developed separately until now. This project will meld these two approaches into a single framework, thereby allowing fast database searches to augment models that can be simulated. Specifically, the project will 1. Develop fast algorithms to search databases of molecular data to suggest extensions to models of cellular control systems 2. Develop new principles to test how well these extended models match experimental data and 3. Design experimental tests that can validate the predictions made by the first two steps. The project will validate this system by studying the mechanism of cell division, a system involved in the development of cancer. In the long term, the methods developed by this project can be used to study any complex cellular system, e.g., those implicated in infectious diseases.

Public Health Relevance

Project Narrative This project will meld two distinct approaches for studying complex cellular systems, one top-down and the other bottom-up, into a single framework. The project will combine the power of fast database searches with hand-crafted models. The project will validate this system by studying the mechanism of cell division, a system involved in the development of cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM095955-02
Application #
8257897
Study Section
Biodata Management and Analysis Study Section (BDMA)
Program Officer
Lyster, Peter
Project Start
2011-05-01
Project End
2016-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
2
Fiscal Year
2012
Total Cost
$375,481
Indirect Cost
$140,217
Name
Virginia Polytechnic Institute and State University
Department
Biostatistics & Other Math Sci
Type
Schools of Engineering
DUNS #
003137015
City
Blacksburg
State
VA
Country
United States
Zip Code
24061
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