We will take a genetic approach to dissect the neuronal circuitry that underlies behavioral aversion of UV, using the Drosophila egg-laying site as our model system.
We aim to identify and characterize both the critical sensory neurons and their post-synaptic targets that govern UV aversion. In addition, we will also assess the roles of neuro-modulatory neurons in adjusting the strength of UV aversion via modulating the communication between the specific sensory and central neurons we identified.
The ability to detect, assess, and respond properly to aversive stimuli is essential for animal survival and reproductive success;failure to sense significant threats causes bodily harm while unchecked sensitivity to mild aversive stimuli may incur opportunity loss as well as stress-induced mental illness. Given that the channel, neuropeptide, and neuro-modulatory systems we are investigating in our proposal all appear to be conserved across species, our findings will likely shed light on how stress is processed in humans.
|Guntur, Ananya R; Gou, Bin; Gu, Pengyu et al. (2017) H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. Genetics 205:749-759|
|Kaneko, Takuya; Macara, Ann Marie; Li, Ruonan et al. (2017) Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila. Neuron 95:623-638.e4|
|Kaneko, Takuya; Macara, Ann Marie; Li, Ruonan et al. (2017) Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila. Neuron 95:722|
|Gou, Bin; Zhu, Edward; He, Ruo et al. (2016) High Throughput Assay to Examine Egg-Laying Preferences of Individual Drosophila melanogaster. J Vis Exp :e53716|
|Guntur, Ananya R; Gu, Pengyu; Takle, Kendra et al. (2015) Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2. Proc Natl Acad Sci U S A 112:E5753-61|
|Stern, Ulrich; He, Ruo; Yang, Chung-Hui (2015) Analyzing animal behavior via classifying each video frame using convolutional neural networks. Sci Rep 5:14351|
|Yang, Chung-Hui; He, Ruo; Stern, Ulrich (2015) Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task. J Neurosci 35:1396-410|
|Stern, Ulrich; Zhu, Edward Y; He, Ruo et al. (2015) Long-duration animal tracking in difficult lighting conditions. Sci Rep 5:10432|
|Gou, Bin; Liu, Ying; Guntur, Ananya R et al. (2014) Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila. Cell Rep 9:522-30|
|Zhu, Edward Y; Guntur, Ananya R; He, Ruo et al. (2014) Egg-laying demand induces aversion of UV light in Drosophila females. Curr Biol 24:2797-804|
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