Over 23 million surgeries are performed each year in the United States. Currently there are no objective measures for pain during surgery. Over the past few years we have developed the use of Near Infrared Spectroscopy (NIRS) to provide an objective measure of pain sensation. Near infrared spectroscopy (NIRS) systems are simple and portable, and easily applicable in the operating room, enabling the physician to measure activity in specific brain regions involved in the sensation of pain (primary somatosensory cortex, SI) or motor planning/escape (supplementary motor cortex, SMA). We have identified a specific pain signal from the supplementary motor and prefrontal cortices. We now propose to advance the NIRS technology to make the measure of this pain biomarker more robust for the clinical environment, validate the measure in controlled clinically relevant conditions, and then demonstrate clinical utility for monitoring pain sensation in an operating room environment. Our hypothesis is that objective measures by NIRS during anesthesia of neural activity in the primary somatosensory and prefrontal cortices in response to an intermittent pain stimulus will reflect the effectiveness of analgesic blockade while under anesthesia.
Three specific aims have been generated to test this hypothesis: (1) To advance NIRS technology for the operating room environment by advancing signal processing to filter systemic interference and dynamically estimate the pain biomarker;(2) To validate objective measure of pain by evaluating analgesic effects of an opioid (morphine) in healthy men and women;and to test for pain measures under sedation in otherwise healthy men and women undergoing colonoscopy;and (3) To translate these measures to patients undergoing inhalational anesthesia or total intravenous anesthesia. Successful completion of the aims will lead towards a new tool for the anesthesiologist to optimize management of the patient to reduce the incidence of peri-operative pain-related sequelae. We have put together an interdisciplinary team (NIRS specialists and pain specialists and physicians) to undertake and complete the proposed studies.

Public Health Relevance

Near infrared spectroscopy has the potential to provide a novel measure of pain sensation. By directly measuring the brain's response to painful stimuli. NIRS is portable and can thus be used in the operating room to provide an objective measure of pain sensation and enable the anesthesiologist to optimize pain management. As a result, NIRS can potentially reduce the significant number of patients who suffer acute pain during surgery and may subsequently suffer from chronic pain and/or post-traumatic stress disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM104986-01
Application #
8445578
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Cole, Alison E
Project Start
2013-02-01
Project End
2016-12-31
Budget Start
2013-02-01
Budget End
2013-12-31
Support Year
1
Fiscal Year
2013
Total Cost
$544,784
Indirect Cost
$231,690
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
YĆ¼cel, Meryem A; Selb, Juliette; Cooper, Robert J et al. (2014) TARGETED PRINCIPLE COMPONENT ANALYSIS: A NEW MOTION ARTIFACT CORRECTION APPROACH FOR NEAR-INFRARED SPECTROSCOPY. J Innov Opt Health Sci 7: