Recent advances in the laboratory sciences have led to the discovery of a large number of candidate biomarkers, which hold great potential for disease diagnosis and treatment. At this time, an important research bottleneck is the lack of well-developed statistical methods for effectively using these candidate biomarkers to enhance clinical practice. It is our goal to develop new tools to select, combine, and evaluate biomarkers for disease classification and treatment selection. Classification markers predict an individual's disease outcome and are useful for the detection of diseases at an early stage when a treatment is most effective. Research proposed in Aim 1 seeks to select and combine markers to improve the classification performance in disease screening and diagnosis. Treatment selection markers predict a patient's response to different therapies and allow for the selection of a therapy that has the best predicted outcome.
Aim 2 seeks to develop marker-based treatment selection rules to maximize the benefit to the patient population. A biomarker that is useful for guiding treatment decision to the general population will have different values to different patients due to individual differences in their response to treatment and in their tolerance of the disease harm and treatment cost.
Aim 3 seeks to develop a new graphical tool to customize the evaluation of a biomarker for aiding treatment decision based on personal characteristics. Our statistical methods will apply broadly to general medical fields. In particulr, we will apply these methods to analyze several cancer studies including (1) biomarker studies for prostate cancer and pan- creatic cancer from the Early Detection and Research Network;(2) the Women's Health Initiative breast cancer genome-wide association study;and (3) the Oncotype-Dx breast cancer study from the Southwest Oncology Group. Programs and algorithms developed in this proposal will be made available to public.

Public Health Relevance

The focus of this proposal is to develop novel statistical methods for the design and analysis of biomarker studies. In particular, the proposed methods will develop marker combinations to improve disease diagnosis, develop treatment selection rules to cost-effectively reduce population disease burden, and help patients and clinicians make informed decisions about the use of medical tests in clinical practices.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Project (R01)
Project #
Application #
Study Section
Cancer Biomarkers Study Section (CBSS)
Program Officer
Sheeley, Douglas
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Fred Hutchinson Cancer Research Center
United States
Zip Code
Fong, Youyi; Yin, Shuxin; Huang, Ying (2016) Combining biomarkers linearly and nonlinearly for classification using the area under the ROC curve. Stat Med 35:3792-809
Huang, Ying; Gilbert, Peter B; Fu, Rong et al. (2016) Statistical methods for down-selection of treatment regimens based on multiple endpoints, with application to HIV vaccine trials. Biostatistics :
Huang, Ying; Laber, Eric (2016) Personalized Evaluation of Biomarker Value: A Cost-Benefit Perspective. Stat Biosci 8:43-65
Huang, Ying (2016) Evaluating and comparing biomarkers with respect to the area under the receiver operating characteristics curve in two-phase case-control studies. Biostatistics 17:499-522
Huang, Ying; Laber, Eric B; Janes, Holly (2015) Characterizing expected benefits of biomarkers in treatment selection. Biostatistics 16:383-99
Gilbert, Peter B; Gabriel, Erin E; Huang, Ying et al. (2015) Surrogate Endpoint Evaluation: Principal Stratification Criteria and the Prentice Definition. J Causal Inference 3:157-175
Kang, Chaeryon; Huang, Ying; Miller, Christopher J (2015) A discrete-time survival model with random effects for designing and analyzing repeated low-dose challenge experiments. Biostatistics 16:295-310
Huang, Ying (2015) Identifying optimal biomarker combinations for treatment selection through randomized controlled trials. Clin Trials 12:348-56
Kang, Chaeryon; Janes, Holly; Huang, Ying (2014) Rejoinder: Combining biomarkers to optimize patient treatment recommendations. Biometrics 70:719-20
Huang, Ying; Fong, Youyi (2014) Identifying optimal biomarker combinations for treatment selection via a robust kernel method. Biometrics 70:891-901

Showing the most recent 10 out of 12 publications