Recent advances in the laboratory sciences have led to the discovery of a large number of candidate biomarkers, which hold great potential for disease diagnosis and treatment. At this time, an important research bottleneck is the lack of well-developed statistical methods for effectively using these candidate biomarkers to enhance clinical practice. It is our goal to develop new tools to select, combine, and evaluate biomarkers for disease classification and treatment selection. Classification markers predict an individual's disease outcome and are useful for the detection of diseases at an early stage when a treatment is most effective. Research proposed in Aim 1 seeks to select and combine markers to improve the classification performance in disease screening and diagnosis. Treatment selection markers predict a patient's response to different therapies and allow for the selection of a therapy that has the best predicted outcome.
Aim 2 seeks to develop marker-based treatment selection rules to maximize the benefit to the patient population. A biomarker that is useful for guiding treatment decision to the general population will have different values to different patients due to individual differences in their response to treatment and in their tolerance of the disease harm and treatment cost.
Aim 3 seeks to develop a new graphical tool to customize the evaluation of a biomarker for aiding treatment decision based on personal characteristics. Our statistical methods will apply broadly to general medical fields. In particular, we will apply these methods to analyze several cancer studies including (1) biomarker studies for prostate cancer and pancreatic cancer from the Early Detection and Research Network; (2) the Women's Health Initiative breast cancer genome-wide association study; and (3) the Oncotype-Dx breast cancer study from the Southwest Oncology Group. Programs and algorithms developed in this proposal will be made available to public.

Public Health Relevance

The focus of this proposal is to develop novel statistical methods for the design and analysis of biomarker studies. In particular, the proposed methods will develop marker combinations to improve disease diagnosis, develop treatment selection rules to cost-effectively reduce population disease burden, and help patients and clinicians make informed decisions about the use of medical tests in clinical practices.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
4R01GM106177-04
Application #
8996183
Study Section
Cancer Biomarkers Study Section (CBSS)
Program Officer
Marcus, Stephen
Project Start
2013-05-10
Project End
2019-01-31
Budget Start
2017-02-01
Budget End
2018-01-31
Support Year
4
Fiscal Year
2017
Total Cost
$291,377
Indirect Cost
$120,377
Name
Fred Hutchinson Cancer Research Center
Department
Type
Research Institutes
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Fong, Youyi; Huang, Ying; Lemos, Maria P et al. (2017) Rank-based two-sample tests for paired data with missing values. Biostatistics :
Kim, Soyoung; Huang, Ying (2017) Combining biomarkers for classification with covariate adjustment. Stat Med 36:2347-2362
Huang, Ying (2017) Evaluating principal surrogate markers in vaccine trials in the presence of multiphase sampling. Biometrics :
Fong, Youyi; Huang, Ying; Gilbert, Peter B et al. (2017) chngpt: threshold regression model estimation and inference. BMC Bioinformatics 18:454
Huang, Ying; Gilbert, Peter B; Fu, Rong et al. (2017) Statistical methods for down-selection of treatment regimens based on multiple endpoints, with application to HIV vaccine trials. Biostatistics 18:230-243
Spieker, Andrew J; Huang, Ying (2017) A method to address between-subject heterogeneity for identification of principal surrogate markers in repeated low-dose challenge HIV vaccine studies. Stat Med 36:4071-4080
Gilbert, Peter B; Huang, Ying (2016) Predicting Overall Vaccine Efficacy in a New Setting by Re-Calibrating Baseline Covariate and Intermediate Response Endpoint Effect Modifiers of Type-Specific Vaccine Efficacy. Epidemiol Methods 5:93-112
Fong, Youyi; Yin, Shuxin; Huang, Ying (2016) Combining biomarkers linearly and nonlinearly for classification using the area under the ROC curve. Stat Med 35:3792-809
Huang, Ying; Laber, Eric (2016) Personalized Evaluation of Biomarker Value: A Cost-Benefit Perspective. Stat Biosci 8:43-65
Huang, Ying (2016) Evaluating and comparing biomarkers with respect to the area under the receiver operating characteristics curve in two-phase case-control studies. Biostatistics 17:499-522

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