The goal of this research is to uncover the stepwise process by which new morphological structures and the networks that control their development evolve. Each and every morphological structure evolved at some point in the past, and our understanding of the origins of the developmental networks that spatially orchestrate development is still a mystery. It is becoming increasingly appreciated that our understanding of these networks at the molecular level will lie at the heart of connecting genetic variation to differences in phenotype, including the predisposition to disease. By characterizing a recently evolved morphological novelty of Drosophila melanogaster, this project will provide a unique perspective on how networks arise and are altered to generate differences in three dimensional forms.

Public Health Relevance

Gene regulatory networks lie at the core of development. The goal of this research is to understand how networks arise and change, generating morphological complexity. Understanding how these networks evolve will provide a unique perspective of their construction and operation, impacting our understanding of human health and variation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM107387-01A1
Application #
8695585
Study Section
Development - 1 Study Section (DEV1)
Program Officer
Hoodbhoy, Tanya
Project Start
2014-04-05
Project End
2019-03-31
Budget Start
2014-04-05
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$321,774
Indirect Cost
$96,774
Name
University of Pittsburgh
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213