The goal of this research is to uncover the stepwise process by which new morphological structures and the networks that control their development evolve. Each and every morphological structure evolved at some point in the past, and our understanding of the origins of the developmental networks that spatially orchestrate development is still a mystery. It is becoming increasingly appreciated that our understanding of these networks at the molecular level will lie at the heart of connecting genetic variation to differences in phenotype, including the predisposition to disease. By characterizing a recently evolved morphological novelty of Drosophila melanogaster, this project will provide a unique perspective on how networks arise and are altered to generate differences in three dimensional forms.
Gene regulatory networks lie at the core of development. The goal of this research is to understand how networks arise and change, generating morphological complexity. Understanding how these networks evolve will provide a unique perspective of their construction and operation, impacting our understanding of human health and variation.
|Smith, Andrew F; Posakony, James W; Rebeiz, Mark (2017) Automated tools for comparative sequence analysis of genic regions using the GenePalette application. Dev Biol 429:158-164|
|Rebeiz, Mark; Tsiantis, Miltos (2017) Enhancer evolution and the origins of morphological novelty. Curr Opin Genet Dev 45:115-123|
|Glassford, William J; Johnson, Winslow C; Dall, Natalie R et al. (2015) Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty. Dev Cell 34:520-31|
|Rebeiz, Mark; Patel, Nipam H; Hinman, Veronica F (2015) Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development. Annu Rev Genomics Hum Genet 16:103-31|